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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2001 / Cilt: 30 - Sayı: 3

An investigation on the effect of N-nitrosopyrollidine on the rabbit liver and kidney glutathione-s-transferase activity in vitro

İn vitro şartlarda N-nitrozoprolidin'in tavşan karaciğer ve böbrek glutatyon-s-transferaz aktivitesine etkisinin araştırılması

İzzet YELKOVAN
İsmihan GÖZE
Sevtap BAKIR
Pages
13–20
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The result were expressed as specific activities.

📌 3 Key Takeaways

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Objective & Hypothesis:We analyzed the interaction of glutation-S-transferase, which is isolated from the liver and kidney of rabbits with N-nitrosopyrollidine which is an effective carcinogenic.
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Key Findings & Data:The activities observed were compared with that of the activity observed in the presence of 1-chloro-2,4-dinitrobenzene as a substrate and a regression analysis was performed to investigate the correlation.
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Conclusion & Impact:The result were expressed as specific activities.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We analyzed the interaction of glutation-S-transferase, which is isolated from the liver and kidney of rabbits with N-nitrosopyrollidine which is an effective carcinogenic. Glutathione-S-transferase enzymes were treated with N-nitrosopyrollidine in vitro conditions at various doses, and the reactions were recorded. The activities observed were compared with that of the activity observed in the presence of 1-chloro-2,4-dinitrobenzene as a substrate and a regression analysis was performed to investigate the correlation. The result were expressed as specific activities.

Özet

Çalışmada tavşan karaciğerinden ve böbreklerinden izole edilen Glutatyon-S-Transferaz'ın kanserojen etkili bir madde olan N-nitrozoprolidin ile etkileşimi incelendi. Glutatyon-S-Transferaz enzimi in vitro şartlarda değişik dozlarda N-nitrozoprolidin ile muamele edilerek, reaksiyonları gözlendi. Bulgular 1-kloro-2,4-dinitrobenzen (KDNB) substrat olarak kullanıldığında bulunan aktivite ile karşılaştırıldı. Regresyon ve korelasyon analizi yapıldı. Sonuçlar spesifik aktivite olarak verildi.

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Cite This Article

YELKOVAN, İ., GÖZE, İ., BAKIR, S. (2022). An investigation on the effect of N-nitrosopyrollidine on the rabbit liver and kidney glutathione-s-transferase activity in vitro. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 30 - Sayı: 3, 13–20. https://ajindex.com/articles/439832

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