Journals / Anatolian Journal of Emergency Medicine / 2020 / Cilt: 3 - Sayı: 4

Changes in Blood Gases in Hypothermia and Respiratory Treatment Goals: Alpha-STAT and pH-STAT Approaches

Hipotermide Kan Gazlarında Gözlenen Değişiklikler Ve Solunumsal Tedavi Hedefleri: Alfa-STAT Ve pH-STAT Yaklaşımları

Pages
135–139
Publication Date
2022-10-12
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, physiological processes occurring in the human body in hypothermia and their reflections on blood gases are evaluated and at the same time, 'Alpha-Stat' and pH-Stat' respiratory treatment strategies, which have completely opposite goals are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In Emergency Medicine practice, hypothermia cases are generally seen with environmental accidents related to cold injuries.
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Key Findings & Data:Therapeutic Hypothermia, or "Targeted Temperature Management", is a neuroprotective treatment method that is thought to increase neurological functions and survival rate after cardiac arrest.
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Conclusion & Impact:In this review, physiological processes occurring in the human body in hypothermia and their reflections on blood gases are evaluated and at the same time, 'Alpha-Stat' and pH-Stat' respiratory treatment strategies, which have completely opposite goals are discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In Emergency Medicine practice, hypothermia cases are generally seen with environmental accidents related to cold injuries. The body temperatures of the cases differ and the ultimate goal in treatment is to reach normal body temperature. Therapeutic Hypothermia, or "Targeted Temperature Management", is a neuroprotective treatment method that is thought to increase neurological functions and survival rate after cardiac arrest. Although the target values and duration of therapy after cardiac arrest have not been clarified, it is known that better neurological outcome is observed compared to those who received standard therapy in the first hours. Therefore, it will be inevitable to apply "Targeted Temperature Management" more widely in emergency services in the coming days. Interpretation of changes in blood gases observed in patients with hypothermia and respiratory therapy strategies that should be applied to carry out cellular physiological processes in a normal course are important problems that have been discussed for many years and there is still no consensus. In this review, physiological processes occurring in the human body in hypothermia and their reflections on blood gases are evaluated and at the same time, 'Alpha-Stat' and pH-Stat' respiratory treatment strategies, which have completely opposite goals are discussed.

Özet

Acil Tıp pratiğinde hipotermi vakaları genellikle soğuk ile ilişkili çevresel kazalar ile birlikte görülür. Vakaların vücut ısıları farklılık gösterir ve tedavide nihai hedef normal vücut sıcaklığına ulaşmaktır. Terapötik hipotermi veya daha çok kabul gören ismi ile ‘Hedeflenmiş Sıcaklık Yönetimi’ ise kardiyak arrest sonrası nörolojik fonksiyonlarda ve hayatta kalma oranında artış sağlayabildiği düşünülen nöroprotektif bir tedavi yöntemidir. Kardiyak arrest sonrası her ne kadar hedef değerler ve uygulama süresi netlik kazanmamış olsa da ilk saatlerde uygulanmaya başlayan hastalarda standart tedavi uygulananlara göre daha iyi nörolojik sonlanımın gözlendiği bilinmektedir. Dolayısıyla önümüzdeki günlerde acil servislerde ‘Hedeflenmiş Sıcaklık Yönetimi’nin daha yaygın uygulanması kaçınılmaz olacaktır. Hipotermi uygulanan hastalarda kan gazlarında gözlenen değişikliklerin yorumlanması ve hücresel fizyolojik süreçleri normal seyrinde yürütmek için uygulanması gereken solunumsal tedavi stratejileri ise uzun yıllardır tartışılmaya devam eden ve üzerinde bir konsensüse varılamamış önemli sorunlardır. Bu derlemede, hipotermide insan vücudunda ortaya çıkan fizyolojik süreçler ve bunun kan gazlarına olan yansımaları değerlendirilmiş ve aynı zamanda bu hasta grubunda uygulanan ve birbirine tamamen zıt hedefleri olan ‘Alfa-Stat’ ve pH-Stat’ solunumsal tedavi yöntemleri tartışılmıştır.

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Cite This Article

ÖZTÜRK, T. C., DOĞAN, F. S., AKOĞLU, E. Ü. (2022). Changes in Blood Gases in Hypothermia and Respiratory Treatment Goals: Alpha-STAT and pH-STAT Approaches. Anatolian Journal of Emergency Medicine, Cilt: 3 - Sayı: 4, 135–139. https://ajindex.com/articles/439359

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References (14)

  1. Dow J, Giesbrecht GG, Danzl DF, et al. Wilderness Medical Society Clinical Practice guidelines for the out-of-hospital evaluation and treatment of accidental hypothermia: 2019 update. Wilderness & environmental medicine. 2019;30(4):47- 69
  2. Paddock MT. Cold Injuries. In:Tintinalli JEed. Emergency Medicine: A Comprehensive Study Guide. 8th ed. New York, NY:McGraw-Hill;2016:1353-1357
  3. Zafren K, Danzl DF. Frostbite and non-freezing cold injuries. In: Walls RM ed. Rosen’s Emergency Medicine Consepts and Clinical Practise. 9th ed. Philedelphia, PA:Elsevier, Inc;2018:1735-1742
  4. Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2020;142:366-468
  5. Lascarrou JB, Merdji H, Le Gouge A, et al. Targeted temperature management for cardiac arrest with nonshockable rhythm. New England Journal of Medicine. 2019:12;381(24):2327-37
  6. Algarni KD, Yanagawa B, Rao V, et al. Profound hypothermia compared with moderate hypothermia in repair of acute type A aortic dissection. The Journal of thoracic and cardiovascular surgery. 2014:148(6):2888-94
  7. Moler FW, Silverstein FS, Holubkov R, et al. Therapeutic hypothermia after in-hospital cardiac arrest in children. New England Journal of Medicine. 2017;376(4):318-29
  8. Kurisu K, Kim JY, You J, et al. Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease. Curr Med Chem. 2019;26(29):5430-5455. doi:10.2174/0929867326666190506124836 9. Brown D. Hypotermia. In: Tintinalli JE ed. Emergency Medicine: A Comprehensive Study Guide. 8th ed. New York, NY:McGrawHill;2016:1357-1365
  9. Severinghaus JW. The invention and development of blood gas analysis apparatus. Anesthesiology. 2002;97(1):253-6
  10. Shapiro BA. Temperature correction of blood gas values. Respiratory Care Clinics of North America. 1995;1(1):69-76
  11. Mohammadhoseini E, Safavi E, Seifi S,et al. Effect of sample storage temperature and time delay on blood gases, bicarbonate and pH in human arterial blood samples. Iranian Red Crescent Medical Journal. 2015;17(3)
  12. Theodore AC, Manaker S, Hollingsworth H. Arterial blood gases. In:UpToDate 2018. UpToDate, Waltham (MA). https://www.uptodate.com/contents/arterial-blood-gases#H6 adresinden 17.01.2021 tarihinde erişilmiştir
  13. Bacher A. Effects of body temperature on blood gases. Intensive care medicine. 2005;31(1):24-7
  14. Andritsch