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Journals / Anatolian Journal of Botany / 2020 / Cilt: 4 - Sayı: 2

The regulatory effects of resveratrol on the expression of renal MMP-2 and MMP-9 in the rat models of diabetes

Resveratrolün sıçan diyabet modellerinde renal MMP-2 ve MMP-9 ekspresyonu üzerindeki düzenleyici etkileri

Gökhan PEKTAŞ
Erhan BOZKURT
Pages
85–91
Publication Date
2022-10-12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Resveratrol has partly modulatory effects on diabetes-induced changes.

📌 3 Key Takeaways

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Objective & Hypothesis:Hyperglycemia caused by diabetesmellitus, in sensitive tissues such as the kidney,can cause dysfunction by damaging the blood vessels.
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Key Findings & Data:Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play a significant role in the degradation of proteins and angiogenesis; while epidermal growth factor receptor (EGFR) is involved in the recovery of damaged tissues.
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Conclusion & Impact:Resveratrol has partly modulatory effects on diabetes-induced changes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hyperglycemia caused by diabetesmellitus, in sensitive tissues such as the kidney,can cause dysfunction by damaging the blood vessels. Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play a significant role in the degradation of proteins and angiogenesis; while epidermal growth factor receptor (EGFR) is involved in the recovery of damaged tissues. Herein, we investigated the relationship between MMP-2 and MMP-9/EGFR in the kidney tissues of streptozotocin-induced Wistar male rats. We also examined the effects of resveratrol known as a strong tissue-protective on these changes. Diabetes was induced bystreptozotocin (55 mg/kg) and trans-resveratrol (20 mg/kg/day intraperitoneal) was used for treatment. Rats were divided into 4 groups as control, resveratrol (Res), diabetes (Diab)and diabetes plus resveratrol (Diab+Res). Superoxide dismutase (SOD) and catalase (CAT) levels were significantly decreased in the kidneys in the diabetic group, whereas nitrite/nitrate, urea, creatine kinase (CK) and uric acid concentrations increased. MMP-2, MMP-9, calcium-binding protein B (S100B)and platelet-derived growth factor (PDGF)concentrations of kidney were increased although reduced EGFR in the diabetes group. Resveratrol supplementation markedly restored all these structures. Diabetes activates MMP related inflammation and oxidative stress by suppressing antioxidant enzymes in the kidney tissues. Resveratrol has partly modulatory effects on diabetes-induced changes.

Özet

Diyabetes mellitusun neden olduğu hiperglisemiböbrek gibi hassas dokularda kan damarlarına zarar vererek işlev bozukluğuna neden olabilir. Matriks metaloproteinazlar (MMP'lar), özellikle MMP-2 ve MMP-9, proteinlerin bozunmasında ve anjiyojenezde önemli bir rol oynarken ;epidermal büyüme faktörü reseptörü (EGFR) hasarlı dokuların iyileşmesinde rol oynar.Burada streptozotosin ile indüklenmiş Wistar erkek sıçanların böbrek dokularında MMP-2 ve MMP-9/EGFR arasındaki ilişkiyi araştırdık. Ayrıcagüçlü doku koruyucu olarak bilinen resveratrolün bu değişiklikler üzerindeki etkilerini inceledik. Diyabet modeli streptozotosin (55 mg/kg) ile oluşturuldu ve tedavi için trans-resveratrol (20 mg/kg/gün intraperitoneal) kullanıldı. Sıçanlar kontrol, resveratrol (Res), diyabet (Diab) ve diyabet + resveratrol (Diab + Res) şeklinde 4 gruba ayrıldı. Diyabet grubundaki sıçanların böbreklerinde superoksitdismutaz(SOD)vekatalaz(CAT)düzeylerinin önemli ölçüde azaldığı buna karşınnitrit/nitrat, üre, kreatinin kinaz (CK) ve ürik asit konsantrasyonlarının arttığı saptanmıştır. Diyabet grubunda renal EGFR düzeyinin azalmasına rağmenMMP-2, MMP-9, kalsiyum bağlayan protein B (S100B)ve trombosit kaynaklı büyüme faktörü(PDGF)düzeyleri artmıştır. Resveratrol takviyesi tüm değişkenleri önemli ölçüde iyileştirdi. Diyabet, böbrek dokularındaki antioksidan enzimleri baskılayarak MMPile ilişkili inflamasyonu ve oksidatif stresi aktive eder. Resveratrol, diyabetin neden olduğu bu değişiklikler üzerinde kısmen modülatör etkilere sahiptir.

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Cite This Article

PEKTAŞ, G., BOZKURT, E. (2022). The regulatory effects of resveratrol on the expression of renal MMP-2 and MMP-9 in the rat models of diabetes. Anatolian Journal of Botany, Cilt: 4 - Sayı: 2, 85–91. https://ajindex.com/articles/439251

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