Journals / Anadolu Tıp Dergisi / 2000 / Cilt: 2 - Sayı: 3

Distribution of HLA-Class-I and HLA-Class-II histocompatibility antigens in chorionic villi in term placentas of preeclampsia

Preeklampside term plasentalarında HLA-Klas-I, HLA-Klas-II histokompatibilite antijenlerinin koryon villuslarında dağılımı

Pages
173–179
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Similarly, in CD68 positive Hofbauer cells in preeclampsia, HLA-DQ expression was more excessive than control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Our aim in this study was to evaluate the distribution of HLA-class I and II antigens in chorion villi of preeclamptic placentas and to compare the obtained data with normal placentas, A total of 45 placentas, 35 preeclamptic and 10 normal, were included in this study.
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Key Findings & Data:HLA-DR, CD68 and F-VIII-RAg immunostaining were performed in paraffin embedded tissue samples by avidivin biotin peroxydase method.
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Conclusion & Impact:Similarly, in CD68 positive Hofbauer cells in preeclampsia, HLA-DQ expression was more excessive than control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Our aim in this study was to evaluate the distribution of HLA-class I and II antigens in chorion villi of preeclamptic placentas and to compare the obtained data with normal placentas, A total of 45 placentas, 35 preeclamptic and 10 normal, were included in this study. HLA-DR, CD68 and F-VIII-RAg immunostaining were performed in paraffin embedded tissue samples by avidivin biotin peroxydase method. HLA-ABC, HLA-DP and HLA-DQ immunostaining was performed in frozen sections of fresh tissue samples. In both groups, the differences between F-VIII-RAg, HLA-DQ and HLA-ABC expression in villous endothelium were found to be statistically significant. Similarly, in CD68 positive Hofbauer cells in preeclampsia, HLA-DQ expression was more excessive than control group (p

Özet

Bu çalışmanın amacı preeklampside plasentada HLA-Klas I ve II antijenlerinin koryon villuslarındaki dağılımını araştırmak ve elde edilen bulguları normal gebeliklere ait plasentalarda izlenen bulgular ile karşılaştırmaktı. Çalışmamıza 35 preeklampsi ve 10 normal gebelik olgusuna ait toplam 45 plasenta dahil edildi. HLA-DR, CD68 ve Faktör VIII ile ilişkili antijen (F-VIII-RAg) boyaması, parafine gömülü doku örneklerinde avidin biotin peroksidaz metodu kullanılarak immunohistokimyasal olarak yapıldı. HLA-ABC, HLA-DP ve HLA-DQ ise taze doku örneklerinin frozen kesitleri kullanılarak boyandı. İki grupta, villus endotelinde F-VIII-RAg, HLA-DQ ve HLA-ABC ekspresyonu arasındaki farkın istatistiksel olarak anlamlı olduğu saptandı. Benzer olarak, preeklampside CD68 ile işaretlenen Hofbauer hücrelerinde HLA-DQ ekspresyonu, kontrol olgularından daha fazla izlendi(p

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Cite This Article

ELPEK, G., ELPEK, G. Ö., KARAVELİ, Ş., SARGIN, F., ÜNER, M. (2022). Distribution of HLA-Class-I and HLA-Class-II histocompatibility antigens in chorionic villi in term placentas of preeclampsia. Anadolu Tıp Dergisi, Cilt: 2 - Sayı: 3, 173–179. https://ajindex.com/articles/438190

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