Journals / Anadolu Tıp Dergisi / 2001 / Cilt: 3 - Sayı: 3

Brain damage and cognitive dysfunction secondary to radiotherapy

Radyoterapiye ikincil gelişen beyin hasarı (Nekroz) ve bellek bozukluğu

Pages
168–172
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The aim of reporting this case is to reveal the importance of following complications secondary to radionecrosis and to discuss interference of memory after radiotherapy which effects temporal lobe structures although cognitive functions generally are spared at this procedures.

📌 3 Key Takeaways

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Objective & Hypothesis:A 70 year-old male patient with right hand dominance was seen at our neurology outpatient clinic because of dullness, carelessness and speech defeat complaints perceived by his relatives.
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Key Findings & Data:There was a history of 30 radiotherapy-gamma knife therapies, for cavernous sinus menengioma and a recent memory defect was noticed at the cognitive examination of the patient while he had major difficulties with visual-spatial processing.
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Conclusion & Impact:The aim of reporting this case is to reveal the importance of following complications secondary to radionecrosis and to discuss interference of memory after radiotherapy which effects temporal lobe structures although cognitive functions generally are spared at this procedures.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A 70 year-old male patient with right hand dominance was seen at our neurology outpatient clinic because of dullness, carelessness and speech defeat complaints perceived by his relatives. At his primary examination, an apathetic state and orientation problem were noticed. There was a history of 30 radiotherapy-gamma knife therapies, for cavernous sinus menengioma and a recent memory defect was noticed at the cognitive examination of the patient while he had major difficulties with visual-spatial processing. MRI showed meningioma and focal and widespread bilateral lesions in temporal and parietal lobes with irregular borders conforming to late radionecrosis. Decreased choline levels were reported at MRS examination, on the other hand. The patient was hospitalised with a diagnosis of memorial ongoing disturbance secondary to radionecrosis. There was an ongoing impairment at his conciousness and deterioration was noticed during this time. The patient died 3 weeks after the hospitalisation. The aim of reporting this case is to reveal the importance of following complications secondary to radionecrosis and to discuss interference of memory after radiotherapy which effects temporal lobe structures although cognitive functions generally are spared at this procedures.

Özet

70 yaşında, sağ elini kullanan erkek hasta; yakınları tarafından farkedilen durgunluk, dikkatsizlik ve konuşma bozukluğu şikayetleriyle nöroloji kliniğine getirildi. İlk muayenesinde apati hali ve oryantasyon problemi mevcuttu. Öz geçmişinde kavernöz sinüs menenjiomu tanısıyla 30 kür radyoterapi-gama knife tedavileri öyküsü olan hastanın kognitif muayenesinde yakın bellek kusuru saptanırken, görsel-mekansal işlevlerin ağır derecede bozuk olduğu görüldü. Magnetik Rezonanslı Görüntülemelerinde (MRG) menejiom ve bilateral temporal ve parietal loblarda fokal ve yaygın, geç dönem radyonekroz görünümüyle uyumlu, düzgün sınırlı olmayan lezyonlar izlendi. Magnetik Rezonanslı Spektroskopi (MRS) incelemesinde azalmış kolin düzeyleri rapor edildi. Radyonekroza ikincil gelişen bellek bozukluğu tanısıyla hastaneye yatırılan ve takibe alınan olgunun bilinç bozukluğunda artış görüldü. Hastaneye yatışını takibeden üç haftalık süreç sonunda hasta kaybedildi. Olgumuz, radyoterapiye ikincil komplikasyonların takibini vurgulamak ve kognitif fonksiyonların genelde korunmasına rağmen ; temporal lob yapısını etkileyen radyoterapinin bellek üzerindeki etkisini tartışmak amacıyla sunuldu.

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Cite This Article

GÖZKE, E., KOÇER, E., KOÇER, A. (2022). Brain damage and cognitive dysfunction secondary to radiotherapy. Anadolu Tıp Dergisi, Cilt: 3 - Sayı: 3, 168–172. https://ajindex.com/articles/438156

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