Journals / Anadolu Kardiyoloji Dergisi / 2002 / Cilt: 2 - Sayı: 2

Should troponin-T be assessed during exercise stress testing in patients with stable angina pectoris?

Stabil angina pektorisli hastalarda efor testi sırasında troponin-T değerlendirilmeli mi?

Pages
132–137
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The study of post-stress test troponin T readings, in patients with stable angina pectoris and with negative stress test result, may be of great help in detecting especially the patients with multiple vessel disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study was planned to investigate whether or not troponin-T positivity has occurred during exercise stress testing in patients with stable angina pectoris and if yes, its relationship with the severity of the disease.
📊
Key Findings & Data:Troponin- T was studied 3 times: immediately before, 6 and 24 hours after the exercise testing.
💡
Conclusion & Impact:The study of post-stress test troponin T readings, in patients with stable angina pectoris and with negative stress test result, may be of great help in detecting especially the patients with multiple vessel disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study was planned to investigate whether or not troponin-T positivity has occurred during exercise stress testing in patients with stable angina pectoris and if yes, its relationship with the severity of the disease. Methods: One hundred patients with stable angina pectoris who presented with typical chest pain were included in this study. They were subjected to the exercise stress testing according to Bruce protocol. Troponin- T was studied 3 times: immediately before, 6 and 24 hours after the exercise testing. Coronary angiography was performed two hours after the last blood sampling. Results: Exercise stress test was found positive in 67 (67%) and negative in 33 (33%) patients. Coronary artery disease was present in 47 (70.1%) of those with positive and in 17 (51.5%) with negative test results. Troponin-T was negative in all the patients before the stress test. Troponin-T was found positive in readings taken 6 and 24 hours after the test in 4 patients (6.2%) with coronary artery disease. Of these patients, 2 had positive and the remaining 2 had negative stress test results. Troponin-T was found negative in readings after the stress test in all the patients without coronary artery disease. The duration of the exercise stress test was found to be significantly shorter in patients with troponin positivity than their counterparts with negativity (277.5±81 sec vs. 428.8±195 sec, p=0.024). Troponin-T positivity after the stress test was found considerably higher in patients with three-vessel disease (p=0.021). Conclusions: Heavy exercises like stress test may severely lead to myocardial damage. The study of post-stress test troponin T readings, in patients with stable angina pectoris and with negative stress test result, may be of great help in detecting especially the patients with multiple vessel disease.

Özet

Objective: This study was planned to investigate whether or not troponin-T positivity has occurred during exercise stress testing in patients vvith stable angina pectoris and if yes, its relationship with the severity of the disease. Methods: One hundred patients vvith stable angina pectoris who presented with typical chest pain vvere inc-luded in this study. They vvere subjected to the exercise stress testing according to Bruce protocol. Tropo-nin-T was studied 3 times: immediately before, 6 and 24 hours after the exerdse testing. Coronary angiog-raphy was performed two hours after the last blood sampling. Results: Exercise stress test vvas found positive in 67 (67%) and negative in 33 (33%) patients. Coronary artery disease vvas present in 47 (70.1%) of those vvith positive and in 17 (51.5%) with negative test results. Troponin-T vvas negative in ali the patients before the stress test. Troponin-T was found positive in readings taken 6 and 24 hours after the test in 4 patients (6.2%) with coronary artery disease. Of these patients, 2 had positive and the remaining 2 had negative stress test results. Troponin-T was found negative in readings after the stress test in ali the patients without coronary artery disease. The duration of the exercise stress test vvas found to be significantly shorter in patients vvith troponin positivity than their counterparts with ne-gativity (277.5+81 seç vs. 428.8±195 seç, p=0.024). Troponin-T positivity after the stress test was found con-siderably higher in patients with three-vessel disease (p=0.021). Conclusions: Heavy exercises like stress test may severely lead to myocardial damage. The study of post-stress test troponin T readings, in patients vvith stable angina pectoris and with negative stress test result, may be of great help in detecting especially the patients with multiple vessel disease.

🔖

Cite This Article

ÇİÇEK, Y., TOPSAKAL, R., ÖZDOĞRU, İ., ERYOL, N. K., ÇETİN, S., BAŞAR, E., OĞUZHAN, A., ABACI, A. (2022). Should troponin-T be assessed during exercise stress testing in patients with stable angina pectoris?. Anadolu Kardiyoloji Dergisi, Cilt: 2 - Sayı: 2, 132–137. https://ajindex.com/articles/437561

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Chaitman BR. Exercise stress testing. In: Heart Disease. Braunwald E, ed. Philadelphia: W.B. Saunders Company; 1997. p.153-76
  2. Lindahl B, Andren B, Ohlsson J, et al. Risk stratification in unstable coronary artery disease. Additive value of troponin-T determinations to pre-discharge exercise test. Eur Heart J 1997; 18: 762-70
  3. Safatrom K, Lindhal B, Swahn E. Risk stratification in unstable coronary artery disease-exercise test and troponin-T form a gender perspective. FRISC-Study Group. Fragmin during In Stability in Coronary artery disease. J Am Coll Cardiol 2000; 35: 1791-800
  4. Lindahl B, Venge P, Wallentin L. The FRISC experience with troponin T. Use as decision tool and comparison with other prognostic markers. Eur Heart J 1998; 19 (Suppl N): 51-8
  5. Luscher MS, Thygesen K, Ravkilde J, et al. Applicability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease. TRIM Study Group. Thrombin Inhibition in Myocardial ischemia. Circulation 1997; 96: 2578-85
  6. Johnson PA, Goldman L, Sacks DB, et al. Cardiac troponin T as a marker for myocardial ischemia in patients seen at the emergency department for acute chest pain. Am Heart J 1999; 137: 1137-44
  7. Fearon WF, Lee FH, Froelicher VF. Does elevated cardiac troponin I in patients with unstable angina predict ischemia on stress testing? Am J Cardiol 1999; 84: 1440-2
  8. The principal Investigators of CASS and their Associates. The National Heart, Lung and Blood Institute Coronary Artery Surgery Study (CASS). Circulation 1981; 63 (Suppl 1): 11-81
  9. Gerhardt W, Katus H, Ravkilde J, et al. S-Troponin T in suspected ischemic myocardial injury compared with mass and catalytic concentrations of creatine kinase isoenzyme MB. Clin Chem 199; 37: 1405-11
  10. Kondo K, Aoki H, Ohira K, et al. Does increased serum troponin T indicate clinical severity in unstable angina? (Abstract) Eur Heart J 1994; 15 (suppl): 220
  11. Hamm CW, Goldmann BU, Heeschen C, et al. Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med 1997; 337: 1648-53
  12. Collinson PO, Moseley D, Stubbs PJ, et al. Troponin T for the differential diagnosis of ischemic myocardial damage. Ann Clin Biochem 1993; 30: 11-6
  13. Jurlander B, Farhi ER, Banas JJ Jr, et al. Coronary angiographic findings and troponin T in patients with unstable angina pectoris. Am J Cardiol 2000; 85: 810-4
  14. Frey N, Muller-Bardorff M, Katus HA. Valu