AI Summary & Key Takeaways
AI InsightThis impairment is more advanced in patients with concentric hypertrophy than in those with the other LV geometric patterns.
📌 3 Key Takeaways
Abstract
Objective: The aim of this study was to investigate the relationship between the myocardial performance index (MPI) and left ventricular (LV) geometry in hypertensive patients. Methods: The MPI, which is a marker of systolic and diastolic ventricular function, was measured in 64 hypertensive patients and in 15 healthy persons (Control). According to the value of relative wall thickness (RWT) and LV mass index (LVMI), hypertensive patients were subdivided into four groups: normal (N), 17 patients (26.6%); concentric remodeling (CR), 21 patients (32.8%); concentric hypertrophy (CH), 16 patients (25%); and eccentric hypertrophy (EH), 10 patients (15.6%). Results: A higher MPI was found in all patient groups (N, 0.56 ± 0.11; CR, 0.59 ± 0.11; CH, 0.68 ± 0.19; EH, 0.57 ± 0.10) compared with the controls (0.44 ± 0.09) (p = 0.004, p < 0.001, p < 0.001 and p = 0.002, respectively). In the CH group, the MPI was also higher than in N, CR and EH groups (p = 0.006, p < 0.03 and p = 0.009, respectively). No significant difference was found among N, CR and EH groups. The MPI was correlated with LVMI (r = 0.28, p = 0.014), RWT (r = 0.24, p = 0.035) and interventricular septum diastolic thickness (r = 0.32, p = 0.004).Conclusion: The systolic and diastolic LV functions are impaired in all subgroups of hypertensive patients according to their LV geometry compared to control group. This impairment is more advanced in patients with concentric hypertrophy than in those with the other LV geometric patterns.
Özet
Amaç: Çalışmamızın amacı, hipertansif hastalarda sol ventrikül (SV) geometrisi ile miyokardiyal performans indeksi (MPİ) arasındaki ilişkiyi araştırmaktır. Yöntem: Sistolik ve diyastolik ventriküler fonksiyonun bir göstergesi olan MPİ, 64 hipertansif hastada ve 15 sağlıklı bireyde (kontrol) hesaplandı. Göreceli duvar kalınlığı (GDK) ve SV kitle indeksine (SVKİ) göre hipertansif hastalar 4 alt gruba ayrıldı: normal (N), 17 hasta (% 26.6); konsantrik yeniden biçimlenme (KR), 21 hasta (%32.8); konsantrik hipertrofi (KH), 16 hasta (%25); eksantrik hipertrofi (EH), 10 hasta (%15.6). Bulgular: Miyokardiyal performans indeksi, kontrol grubu ile karşılaştırıldığında (0.44 ± 0.09), tüm hasta gruplarında daha yüksek bulundu (N, 0.56 ± 0.11; KR, 0.59 ± 0.11; KH, 0.68 ± 0.19; EH, 0.57 ± 0,10) (sırasıyla, p = 0.004, p < 0.001, p < 0.001 ve p = 0.002). Ayrıca MPI, KH grubunda N, KR ve EH gruplarından da daha yüksek idi (sırasıyla, p = 0.006, p < 0.03 ve p = 0.009). Normal, KR ve EH grupları arasında anlamlı farklılık görülmedi. Miyokardiyal performans indeksi, SVKİ ile (r = 0.28, p = 0.014), GDK ile (r = 0.24, p = 0.035) ve interventriküler septum diyastolik kalınlığı ile (r = 0,32, p = 0.004) ilişkili bulundu. Sonuç: Hipertansif hastalarda SV sistolik ve diyastolik fonksiyonları SV geometrik paternine göre tüm alt gruplarda kontrol grubuna göre bozulmaktadır. Bu bozukluk SV konsantrik hipertrofisi olan hastalarda, diğer sol ventrikül geometrilerine sahip olanlara göre daha ileri düzeydedir.