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Journals / Anadolu Kardiyoloji Dergisi / 2004 / Cilt: 4 - Sayı: 4

Kalp cerrahisinde kullanılan enalaprilat infüzyonunun hemodinamik değişkenlere ve böbrek fonksiyonlarına etkisi

Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery

Pınar ZEYNELOĞLU
Atilla SEZGİN
Handan TÜRKER
Aslı DÖNMEZ
Melek ULUÇAM
Pages
296–300
Publication Date
2022-10-10
DOI
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Results: In the control group postoperative blood creatinine and urea levels were significantly higher and CLcr measurements were significantly lower than the preoperative values (p0.05), but SVR was lower (p

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Objective & Hypothesis:Objective: This study was undertaken to evaluate the effect of Enalaprilat infusion on hemodynamics and renal function during cardiopulmonary bypass (CPB).Methods: Thirty adults undergoing CPB were randomly allocated into 2 groups.
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Key Findings & Data:All patients received the same anesthetic protocol and same dopamine infusion protocol (2 mg/kg -1/min-1) during the study.
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Conclusion & Impact:Results: In the control group postoperative blood creatinine and urea levels were significantly higher and CLcr measurements were significantly lower than the preoperative values (p0.05), but SVR was lower (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study was undertaken to evaluate the effect of Enalaprilat infusion on hemodynamics and renal function during cardiopulmonary bypass (CPB).Methods: Thirty adults undergoing CPB were randomly allocated into 2 groups. All patients received the same anesthetic protocol and same dopamine infusion protocol (2 mg/kg -1/min-1) during the study. In addition to dopamine infusion 15 patients received enalaprilat infusion (0.06 mg/kg-1/hr-1) during CPB. Blood creatinine, urea levels, and creatinine clearance (CLcr) were measured and cardiac output (CO) was calculated by echocardiography preoperatively and on the 6th postoperative day. Mean arterial pressure (MAP), central venous pressure (CVP), systemic vascular resistance (SVR) measurements were recorded during the operation and during postoperative 24 hours. Results: In the control group postoperative blood creatinine and urea levels were significantly higher and CLcr measurements were significantly lower than the preoperative values (p0.05), but SVR was lower (p

Özet

Amaç: Kardiyopulmoner baypas (KPB) sırasında kullanılan enalaprilat infüzyonunun hemodinamik değişkenlere ve böbrek fonksiyonlarına etkisini araştırmak.Yöntemler: Kardiyopulmoner baypas yapılacak 30 erişkin hasta rastgele olarak iki gruba ayrıldı. Tüm hastalarda standart anestezi yöntemi ve çalışma süresince dopamin infüzyonu kullanıldı (2 mg/kg–1/dak-1). Birinci grup hastalara (n=15) KPB sırasında enalaprilat infüzyonu (0.06 mg/kg-1/st-1) uygulandı. Preoperatif dönemde ve postoperatif 6. günde serum kreatinin ve üre düzeyleri ile kreatinin klirensleri (KLkr) ölçüldü ve ekokardiyografi ile kalp debileri hesaplandı. Ameliyat sırasında ve postoperatif 24 saat boyunca ölçülen ortalama arter basıncı (OAB), santral venöz basınç (SVB) ve sistemik vasküler rezistans (SVR) değerleri kaydedildi. Bulgular: Kontrol grubunun postoperatif dönemdeki kreatinin ve üre düzeyleri preoperatif döneme kıyasla anlamlı olarak yüksek, KLkr ölçümleri ise anlamlı olarak düşük bulundu (p0.05) enalaprilat grubunun SVR ölçümleri kontrol grubuna kıyasla anlamlı olarak düşük (p

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Cite This Article

ZEYNELOĞLU, P., SEZGİN, A., TÜRKER, H., DÖNMEZ, A., ULUÇAM, M. (2022). Kalp cerrahisinde kullanılan enalaprilat infüzyonunun hemodinamik değişkenlere ve böbrek fonksiyonlarına etkisi. Anadolu Kardiyoloji Dergisi, Cilt: 4 - Sayı: 4, 296–300. https://ajindex.com/articles/437451

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