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Journals / Anadolu Kardiyoloji Dergisi / 2004 / Cilt: 4 - Sayı: 1

Romatizmal mitral yetersizliğinde efektif regürjitan orifisi: Anjiyotensin konverting enzim inhibitörü tedavisine cevap

Effective regurgitant orifice area of rheumatic mitral insufficiency: Response to angiotensin converting enzyme inhibitor treatment

Serdar KULA
Rana OLGUNTÜRK
Deniz OĞUZ
F. Sedef TUNAOĞLU
Pages
3–7
Publication Date
2022-10-10
DOI
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Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin.Results: Study group’s left ventricular end-diastolic volume (108.03±41.21 ml/m2), mitral stroke volume (510.37±321.58 ml/m2) and regurgitant volume (423.48±305.00 ml/m2) were significantly higher (p

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Objective & Hypothesis:Objective: This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements.
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Key Findings & Data:Methods: Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males aged 10-18years, body surface area 1.49±0.05m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17years, body surface area 1.38±0.07m2, with no treatment.
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Conclusion & Impact:Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin.Results: Study group’s left ventricular end-diastolic volume (108.03±41.21 ml/m2), mitral stroke volume (510.37±321.58 ml/m2) and regurgitant volume (423.48±305.00 ml/m2) were significantly higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements. Methods: Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males aged 10-18years, body surface area 1.49±0.05m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17years, body surface area 1.38±0.07m2, with no treatment. Patients in the two groups had no symptoms of cardiac failure. Angiotensin converting enzyme inhibitor therapy was given to SG patients on admission. Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin.Results: Study group’s left ventricular end-diastolic volume (108.03±41.21 ml/m2), mitral stroke volume (510.37±321.58 ml/m2) and regurgitant volume (423.48±305.00 ml/m2) were significantly higher (p

Özet

Amaç: Bu çalışma romatizmal mitral yetersizliğini ekokardiyografik ölçümlerle regürjitan volüm (RV), regürjitan fraksiyon (RF) ve efektif regürjitan orifis alanı (EROA)- derecelendirmek ve anjiyotensin konverting enzim inhibitörü (ACEİ) tedavisinin bu ölçümlere olan etkisini belirlemek amacıyla planlanmıştır. Yöntem: Romatizmal mitral yetersizliği olan hastalar: Çalışma grubu (ÇG) (en az 1 yıldır digoksin tedavisi alan 10 kadın, 2 erkek, 10-18 yaş, vücut alanı ort:1.49±0.05m2 ) ve Kontrol grubu (KG) (tedavi almayan 8 kadın, 4 erkek, 8-17 yaş, vucüt alanı 1.38±m2) olmak üzere iki gruba ayrılarak incelenmiştir. Her iki grupta da kalp yetersizliği bulgusu olan hasta bulunmamaktadır. Grupların ekokardiyografik ölçümleri yapıldıktan sonra ÇG’nun tedavisine ACEİ tedavisi eklenmiş ve ACEİ tedavisinin 20. günü ölçümler yinelenmiştir.Sonuçlar: Çalışma grubunun sol ventrikül diyastolik volumü (108.03±41.21 ml/m2), mitral strok volumü (510.37±321.58 ml/m2) ve regürjitan volumü (423.48±305.00 ml/m2) olup, KG’nun değerlerinden sırasıyla (81.98±21.53 ml/m2, 315.34±207.38mL/m2, 245.77±179.84ml/m2) belirgin olarak yüksek bulunmuş (p

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Cite This Article

KULA, S., OLGUNTÜRK, R., OĞUZ, D., TUNAOĞLU, F. S. (2022). Romatizmal mitral yetersizliğinde efektif regürjitan orifisi: Anjiyotensin konverting enzim inhibitörü tedavisine cevap. Anadolu Kardiyoloji Dergisi, Cilt: 4 - Sayı: 1, 3–7. https://ajindex.com/articles/437442

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