SavedAdd your journal

Journals / Anadolu Kardiyoloji Dergisi / 2006 / Cilt: 6 - Sayı: 4

Nitrik oksit ve kardiyovasküler sistem

Nitric oxide and cardiovascular system

Atiye ÇENGEL
Asife ŞAHİNARSLAN
Pages
364–368
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It also includes the latest improvements in the diagnosis and treatment of endothelial dysfunction.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Endothelium has many important functions including the control of blood-tissue permeability and vascular tonus, regulation of vascular surface properties for homeostasis and inflammation.
📊
Key Findings & Data:Nitric oxide is the chief molecule in regulation of endothelial functions.
💡
Conclusion & Impact:It also includes the latest improvements in the diagnosis and treatment of endothelial dysfunction.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Endothelium has many important functions including the control of blood-tissue permeability and vascular tonus, regulation of vascular surface properties for homeostasis and inflammation. Nitric oxide is the chief molecule in regulation of endothelial functions. Nitric oxide deficiency, which is also known as endothelial dysfunction, is the first step for the occurrence of many disease states in cardiovascular system including heart failure, hypertension, dyslipidemia, insulin resistance, diabetes mellitus, hyperhomocysteinemia and smoking. This review deals with the importance of nitric oxide for cardiovascular system. It also includes the latest improvements in the diagnosis and treatment of endothelial dysfunction.

Özet

Endotel, vasküler fonksiyonların normal bir şekilde yürüyebilmesinde son derece önemli görevlere sahip bir organdır. Endotel disfonksiyonu kardiyovasküler sistemi ilgilendiren birçok hastalığın bir parçasıdır. Endotel fonksiyonlarının düzenlenmesinde en önemli aracı moleküllerden biri nitrik oksittir. Bu derlemede nitrik oksidin kardiyovasküler sistem açısından önemi anlatılmıştır. Nitrik oksit eksikliği endotel disfonksiyonuna yol açarak, kardiyovasküler sistemi hedef alan birçok hastalığa zemin hazırlayabilir. Bu yazıda ayrıca, endotel disfonksiyonunun tanısı ve tedavisindeki son gelişmeler üzerinde durulmuştur.

🔖

Cite This Article

ÇENGEL, A., ŞAHİNARSLAN, A. (2022). Nitrik oksit ve kardiyovasküler sistem. Anadolu Kardiyoloji Dergisi, Cilt: 6 - Sayı: 4, 364–368. https://ajindex.com/articles/437273

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Behrendt D, Ganz P. Endothelial function: from vascular biology to clinical applications. Am J Cardiol 2002; 90 (suppl): 40L-8L
  2. Tentolouris C, Tousoulis D, Goumas G, Stefanadis C, Davies G, Toutouzas P. L-Arginine in coronary atherosclerosis. Int J Cardiol 2000; 75: 123-8
  3. Gorren ACF, Schrammel A, Schmidt K, Mayer B. Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition and enzyme stabilization. Biochemistry 1997; 36: 4360-6
  4. Damy T,Ratajczak P, Shah AM, Camons E, Marty I, Hasenfuss G, et al. Increased neuronal nitric oxide synthase-derived NO production in the failing human heart. Lancet 2004; 363: 1365-7
  5. Paulus WJ, Bronzwaer JG. Myocardial contractile effects of nitric oxide. Heart Fail Rev 2002; 7: 371-83
  6. Gealekman O, Abbasi Z, Rubinstein I, Winaver J, Binah O. Role of myocardial inducible nitric oxide synthase in contractile dysfunction and beta-adrenergic hyporesponsiveness in rats with experimental volume-overload heart failure. Circulation 2002; 105: 236-43
  7. Saito T, Hu F, Tayara L, Fahas L, Shennib H, Giaid A. Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure. Am J Physiol Heart Circ Physiol 2002; 283: H339-45
  8. Cotter G, Kaluski E, Blatt A, Milovanov O, Moshkovitz Y, Zaidenstein R, et al. L-NMMA ( a nitric oxide synthase inhibitor) is effective in the treatment of cardiogenic shock. Circulation 2000; 101: 1358-61
  9. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW: Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994; 74: 1141-8
  10. Matsuoka H, Itoh S, Kimoto M, Kohno K, Tamai O, Wada Y,, et al. Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor; in experimental hypertension. Hypertension 1997; 29: 242-7
  11. Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO 3rd, Panza JA. Selective defect in nitric oxide synthesis may explain the impaired endothelium-dependent vasodilation in patients with essential hypertension. Circulation 1998; 97: 851-6
  12. Zizek B, Poredos P, Videenik V. Endothelial dysfunction in hypertensive patients and in normotensive offspring subjects with essential hypertension. Heart 2001; 85: 215-7
  13. Kuzkaya N, Weismann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 2003; 278: 22546-54