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Journals / Anadolu Kardiyoloji Dergisi / 2006 / Cilt: 6 - Sayı: 3

Akut miyokard infarktüsünde G-CSF - Deneysel ve klinik bulgular

G-CSF in acute myocardial infarction - Experimental and clinical findings

Hüseyin İNCE
Michael PETZSCH
Tim C. REHDERS
Simone DUNKELMANN
Christoph A. NIENABER
Pages
261–263
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Early data from clinical studies suggest that intracoronary injection of autologous progenitor cells may beneficially affect postinfarction remodeling and perfusion.
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Key Findings & Data:Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobilization of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections.
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Conclusion & Impact:It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Early data from clinical studies suggest that intracoronary injection of autologous progenitor cells may beneficially affect postinfarction remodeling and perfusion. Beyond intracoronary infusion of autologous bone marrow mononuclear CD34+ cells (MNCCD34+), mobilization of stem cells by G-CSF has recently attracted attention because of various advantages such as the noninvasive nature of MNCCD34+ mobilization by subcutaneous injections. It is the aim of the present work to give an overview about the current experimental and clinical findings of G-CSF treatment in acute myocardial infarction.

Özet

Önceki çalışmalarda otolog progenitör hücrelerin intrakoroner enjeksiyonun infarktüs sonrası yeniden yapılandırmayı (remodeling) ve perfüzyonu yararlı yönde etkilediklerini belirtilmiştir. Kemik iliğinin otolog mononükleer CD34+ hücrelerin (MNCCD34+) intrakoroner infüzyonun ötesinde, kök hücrelerin G-CSF aracılığı ile mobilizasyonu son zamanlarda noninvazif subkutan enjeksiyonlu MNCCD34+ mobilizasyonu gibi farklı avantajlar nedeni ile dikkati üzerine çekmiştir. Bu çalışmanın amacı akut infarktüsünde G-CSF tedavisinin güncel deneysel ve klinik bulguları gözden geçirmektir.

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Cite This Article

İNCE, H., PETZSCH, M., REHDERS, T. C., DUNKELMANN, S., NIENABER, C. A. (2022). Akut miyokard infarktüsünde G-CSF - Deneysel ve klinik bulgular. Anadolu Kardiyoloji Dergisi, Cilt: 6 - Sayı: 3, 261–263. https://ajindex.com/articles/437265

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