AI Summary & Key Takeaways
AI InsightAdditional multicenter stud-ies with larger patient groups should be conducted to obtain more data.
📌 3 Key Takeaways
Abstract
Objective: Patients may develop kidney failure because of the contrast agent given during coronary angiography. Renal dysfunction and heartfailure were previously shown to be associated with the development of contrast nephropathy. In our study, we aimed to investigate whetherthere is a relationship between subclinical renal (indicated by microalbuminuria) and/or cardiac (indicated by the height of the BNP) dysfunc-tion between the development of contrast-induced nephropathy on patients undergoing angiography due to acute coronary syndrome.Methods: This is an observational prospective cohort study. A total of 170 patients hospitalized with a diagnosis of acute coronary syndrome inthe coronary care unit were included in this study. Blood samples were collected from 145 patients without microalbuminuria and 25 patientswith microalbuminuria to determine their BNP levels before coronary angiography. The patients urea and creatinine levels were examinedbefore and 72 h after coronary angiography. Statistical analysis was performed using Kolmogorov-Smirnov test, Mann-Whitney U test, indepen-dent samples t-test and the chi-square test.Results: The study subjects included 82 females and 88 males (average age, 64.4±14.5 years). The BNP levels and height distribution of the 145patients without microalbuminuria were compared between those with and without contrast agent-induced nephropathy, but no significantdifference was found (205.6±280.6, 198.0±310.0, p=0.817). Similarly, no relationship between the microalbumin level and contrast agent-inducednephropathy was found in 25 patients.Conclusion: A relationship between BNP, microalbuminuria, and contrast agent-induced nephropathy was not found in patients hospitalized ina coronary care unit with a diagnosis of acute coronary syndrome who were scheduled for coronary angiography. Additional multicenter stud-ies with larger patient groups should be conducted to obtain more data.