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Journals / Anadolu Kardiyoloji Dergisi / 2008 / Cilt: 8 - Sayı: 4

Annesi nikotin almış yeni doğan ratlarda melatoninin nikotine bağlı miyokardiyal hasarı önlemedeki rolü

The protective effect of melatonin on nicotine-induced myocardial injury in newborn rats whose mothers received nicotine

Ali BAYKAN
Nazmi NARİN
Recep SARAYMEN
Figen NARİN
Selda YAVAŞCAN
Hülya AKGÜN
Pages
243–248
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Plasma MDA levels of HDN, HDNM, LDN, and tissue MDA levels of HDN and LDN were significantly higher than in control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Nicotine, one of the most dangerous substances in tobacco, can pass the placenta and affect the fetal hemodynamics.
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Key Findings & Data:Results: Plasma and tissue MDA levels among groups were different (p=0.001 for plasma MDA and p=0.001 for tissue MDA).
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Conclusion & Impact:Plasma MDA levels of HDN, HDNM, LDN, and tissue MDA levels of HDN and LDN were significantly higher than in control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Nicotine, one of the most dangerous substances in tobacco, can pass the placenta and affect the fetal hemodynamics. The aim of this study was to evaluate the protective effects of melatonin on hearts of nicotine exposed newborn rats whose mothers received nicotine. Methods: This is an experimental, randomized, controlled study. Study groups were composed of five groups of rats; high-dose nicotine (HDN), HDN+melatonin (HDNM), low-dose nicotine (LDN), LDN+melatonin (LDNM), control. Myocardial and plasma malondialdehyde (MDA), nitric oxide(NO), glutathione peroxidase (GSHPx) and superoxide dismutase (SOD) were analyzed and myocardial tissue was examined histopathologically. Comparisons of groups were done with Kruskal-Wallis one way analysis test. All pairwise multiple comparisons and the comparisons between control and other groups were done with Dunn’s nonparametric multiple comparison test. Results: Plasma and tissue MDA levels among groups were different (p=0.001 for plasma MDA and p=0.001 for tissue MDA). Plasma MDA levels of HDN, HDNM, LDN, and tissue MDA levels of HDN and LDN were significantly higher than in control group (p

Özet

Amaç: Tütündeki önemli zararlı maddelerden biri olan nikotin plasentayı geçebilir ve fetal hemodinamik dengeyi etkiler. Bu çalışmanın amacı: Hamilelik ve emzirme döneminde annesi nikotin almış yeni doğan ratlarda melatoninin nikotine bağlı miyokardiyal hasarı önlemedeki rolünü araştırmaktır. Yöntemler: Bu çalışma deneysel, randomize ve kontrollü bir çalışmadır. Çalışma grupları sırasıyla yüksek doz nikotin (HDN), HDN+melatonin (HDNM), düşük doz nikotin (LDN), LDN+melatonin (LDNM), kontrol olmak üzere 5 grup rattan oluşmuştur. Miyokardiyal ve plazma malondialdehit (MDA), nitrik oksit (NO), glutatyon peroksidaz (GSHPx) ve süperoksit dismutaz (SOD) çalışıldı ve kalp dokularından histopatolojik analizler yapıldı. Grupların çoklu karşılaştırması Kruskal-Wallis varyans analizi ile yapıldı. Kontrol grubu ile diğer grupların karşılaştırılmasında ve kontrol grubu dışındaki grupların ikili karşılaştırılmasında Dunn’s nonparametrik testi kullanıldı. Bulgular: Gruplardaki plazma ve doku MDA düzeyleri arasında fark bulundu (plazma MDA düzeyleri için p=0.001 ve doku MDA düzeyleri için p=0.001). Plazma MDA seviyeleri HDN, HDNM ve LDN gruplarında, doku MDA düzeyleri HDN ve LDN grubunda kontrol grubuna göre yüksek bulunmuştur (plazma ve doku MDA düzeyleri için p

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Cite This Article

BAYKAN, A., NARİN, N., SARAYMEN, R., NARİN, F., YAVAŞCAN, S., AKGÜN, H. (2022). Annesi nikotin almış yeni doğan ratlarda melatoninin nikotine bağlı miyokardiyal hasarı önlemedeki rolü. Anadolu Kardiyoloji Dergisi, Cilt: 8 - Sayı: 4, 243–248. https://ajindex.com/articles/437043

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