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Journals / Anadolu Kardiyoloji Dergisi / 2008 / Cilt: 8 - Sayı: 5

Türk yetişkinlerinde CETP TaqIB polimorfizmi: Dislipidemi ve metabolik sendrom ilişkisi

CETP TaqIB polymorphism in Turkish adults: Association with dyslipidemia and metabolic syndrome

Evrim KÖMÜRCÜ-BAYRAK
Nihan ERGİNEL-ÜNALTUNA
Mahveş PODA
Steve E. HUMPHERIES
Günay CAN
Altan ONAT
Gülay HERGENÇ
Bilge ÖZSAİT
Pages
324–330
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The B2B2 genotype was associated with elevated high-density lipoprotein -cholesterol (HDL-C) levels (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In this study, our aim was to investigate the association of cholesterol ester transfer protein (CETP) TaqIB polymorphism with the likelihood of metabolic syndrome (MetS).
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Key Findings & Data:Randomly selected sample of 1585 persons were included in the analyses.
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Conclusion & Impact:The B2B2 genotype was associated with elevated high-density lipoprotein -cholesterol (HDL-C) levels (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this study, our aim was to investigate the association of cholesterol ester transfer protein (CETP) TaqIB polymorphism with the likelihood of metabolic syndrome (MetS). Methods: Study was designed as a cross-sectional analysis of the Turkish Adult Risk Factor follow-up study. Randomly selected sample of 1585 persons were included in the analyses. Genomic DNAs were isolated and the genotyping was performed using TaqMan system. ANOVA, Chi-square, univariate analyses and logistic regression models were used to investigate the association of genotypes with clinical and biochemical measurements. Results: The frequencies of the B1B1, B1B2 and the B2B2 genotypes were 33.3%, 46.4% and 20.3%, respectively. The B2B2 genotype was associated with elevated high-density lipoprotein -cholesterol (HDL-C) levels (p

Özet

Amaç: Bu çalışmada, kolesteril ester transfer proteini (CETP) TaqIB polimorfizmi ile metabolik sendrom (MetS) gözlenme riski arasındaki ilişkinin araştırılması amaçlanmıştır. Yöntemler: TEKHARF takip çalışması dahilinde kesitsel olarak dizayn edilen bu çalışmada, rastgele seçilen 1585 kişinin genomik DNA’sı ayrıştırıldı ve TaqMan sistemi kullanılarak genotipleme yapıldı. ANOVA, Ki-kare, tek-yönlü analiz ve lojistik regresyon modelleri kullanılarak genotiplerin klinik ve biyokimyasal ölçütler ile ilişkisi incelendi. Bulgular: B1B1, B1B2 ve B2B2 genotiplerinin frekansları sırası ile %33.3, %46.4 ve %20.3 olarak tespit edildi. B2B2 genotipinin yüksek HDL-K (yüksek dansiteli lipoprotein-kolesterol) seviyeleri ile ilişkili olduğu gözlendi (p

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Cite This Article

KÖMÜRCÜ-BAYRAK, E., ERGİNEL-ÜNALTUNA, N., PODA, M., HUMPHERIES, S. E., CAN, G., ONAT, A., HERGENÇ, G., ÖZSAİT, B. (2022). Türk yetişkinlerinde CETP TaqIB polimorfizmi: Dislipidemi ve metabolik sendrom ilişkisi. Anadolu Kardiyoloji Dergisi, Cilt: 8 - Sayı: 5, 324–330. https://ajindex.com/articles/437001

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