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Journals / Anadolu Kardiyoloji Dergisi / 2008 / Cilt: 8 - Sayı: 1

Role of leucocytes in microvascular malperfusion in reperfused acute myocardial infarction

Reperfüze akut miyokard infarktüsünde mikrovasküler malperfüzyonda lökositlerin rolü

Sabahattin UMMAN
Murat SEZER
Pages
48–50
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, crucial role and effecting mechanisms of the leucocytes in coronary microvascular malperfusion were discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The mechanisms underlying myocardial malperfusion following restoration of epicardial coronary blood flow are likely to be multifactorial.
📊
Key Findings & Data:Generation of excessive oxygen-free radicals, increased myocardial cell calcium, cellular and interstitial edema, endothelial dysfunction, vasoconstrictors, and thromboembolism have been proposed to account for impaired myocardial perfusion.
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Conclusion & Impact:In this review, crucial role and effecting mechanisms of the leucocytes in coronary microvascular malperfusion were discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The mechanisms underlying myocardial malperfusion following restoration of epicardial coronary blood flow are likely to be multifactorial. Generation of excessive oxygen-free radicals, increased myocardial cell calcium, cellular and interstitial edema, endothelial dysfunction, vasoconstrictors, and thromboembolism have been proposed to account for impaired myocardial perfusion. Leucocytes are the most important cellular components, which promote procoagulant milieu at the microvascular level during acute myocardial infarction. In this review, crucial role and effecting mechanisms of the leucocytes in coronary microvascular malperfusion were discussed.

Özet

Akut miyokard infarktüsünde epikardiyal koroner kan akımının sağlanmasını izleyerek oluşan miyokardiyal malperfüzyonun mekanizması multifaktöryeldir. Serbest oksijen radikallerinin oluşması, miyositlerde kalsiyum birikimi, hücresel ve interstisyel ödem, endoteliyal disfonksiyon ve tromboembolizm miyokardiyal perfüzyon bozukluğunun olası sebepleri arasındadır. Lökositler akut miyokard infarktüsünde mikrodolaşımda oluşan prokoagülan ortamın ortaya çıkışından sorumlu en önemli hücresel elemanlardan biridir. Bu derlemede lökositlerin mikrovasküler malperfüzyondaki önemli rolleri ve olası etki mekanizmaları tartışılmıştır.

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Cite This Article

UMMAN, S., SEZER, M. (2022). Role of leucocytes in microvascular malperfusion in reperfused acute myocardial infarction. Anadolu Kardiyoloji Dergisi, Cilt: 8 - Sayı: 1, 48–50. https://ajindex.com/articles/436968

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