Journals / Anadolu Kardiyoloji Dergisi / 2010 / Cilt: 10 - Sayı: 3

The relation of intima-media thickness with endothelial function and left ventricular mass index

Brakiyal arter intima-media kalınlığının endotel fonksiyonu ve sol ventrikül kütle indeksi ile ilişkisi

Pages
220–225
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

IMT was significantly higher in hypertensive group (0.43±0.09 vs 0.33±0.06 mm; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We aimed to investigate the relation of brachial artery intima-media thickness (IMT) with endothelial function and left ventricular mass (LVM).
📊
Key Findings & Data:Methods: Fifty four stage I-II hypertensive patients according to JNC VII who were not taking any medication and 27 age and sex-matched healthy controls were included to this cross-sectional observational study.
💡
Conclusion & Impact:IMT was significantly higher in hypertensive group (0.43±0.09 vs 0.33±0.06 mm; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to investigate the relation of brachial artery intima-media thickness (IMT) with endothelial function and left ventricular mass (LVM). Methods: Fifty four stage I-II hypertensive patients according to JNC VII who were not taking any medication and 27 age and sex-matched healthy controls were included to this cross-sectional observational study. IMT was measured by the same radiologist who was unaware of the patient’s clinical status by using high resolution ultrasound machine. Endothelial function was evaluated by flow mediated dilation (endothelium-dependent vasodilatation, FMD). LVM was calculated by using Devereux method. LVM index (LVMI) was obtained by dividing LVM to body surface area. Mann-Whitney U test was used to compare continuous variables, qualitative variables were compared by Chi-square test and the relations of parameters were evaluated by multiple linear regression analysis. Results: Both groups (hypertensive and control) were similar with respect to age, sex, left ventricular ejection fraction. IMT was significantly higher in hypertensive group (0.43±0.09 vs 0.33±0.06 mm; p

Özet

Amaç: Amacımız brakiyal intima-media kalınlığı (İMK) ile endotel fonksiyonu ve sol ventrikül kütlesi (SVK) arasındaki ilişkiyi ortaya koymaktır. Yöntemler: Enine- kesitli, gözlemsel bu çalışmaya ilaç kullanmayan veya yeni tanı almış JNC 7 kriterlerine göre evre I-II olan 54 hipertansif hasta ile yaş ve cinsiyet uyumlu 27 kontrol alındı. İMK gruplardan habersiz aynı radyolog tarafından yüksek çözünürlüklü ultrasonografi cihazı ile ölçüldü. Endotel fonksiyonunun değerlendirilmesinde, noninvazif en çok kullanılan yöntem olan brakiyal arterden bakılan endotel- bağımlı vazodilatasyon (FMD) yöntemi kullanıldı. SVK Devereux metoduna göre hesaplandı. SVK vücut yüzey alanına bölünerek “sol ventrikül kütle indeksi” (SVKİ) hesaplandı. İki grup arasındaki sürekli değişkenler Mann-Whitney U testi, nitel değişkenler Ki-kare testi ve parametreler arası ilişkiler çoklu lineer regresyon analizi kullanılarak değerlendirildi. Bulgular: Hipertansif ve kontrol grupları ortalama yaş, cinsiyet dağılımı ve sol ventrikül ejeksiyon fraksiyonu bakımından birbirine benzerdi. Hipertansif ve kontrol grubu arasında İMK değeri oldukça anlamlı farklıydı (0.43±0.09 ve 0.33±0.06 mm, p

🔖

Cite This Article

KORKMAZ, H., ÖZBAY, Y., AKBULUT, M., KOÇ, M. (2022). The relation of intima-media thickness with endothelial function and left ventricular mass index. Anadolu Kardiyoloji Dergisi, Cilt: 10 - Sayı: 3, 220–225. https://ajindex.com/articles/436808

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987
  2. PMid:3574413 2. O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002
  3. 18L-21L. doi:10.1016/S0002-9149(02)02957-0 3. Mukherjee D, Yadav JS. Carotid artery intimal-medial thickness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J 2002
  4. PMid:12422142 4. Kahan T: The importance of left ventricular hypertrophy in human hypertension. J Hypertens Suppl 1998
  5. doi:10.1097/00004872-199816010-00005 PMid:9533413 5. Olsen MH, Wachtell K, Meyer C, Hove JD, Palmieri V, Dige-Petersen H, et al. Association between vascular dysfunction and reduced myocardial flow reserve in patients with hypertension: a LIFE substudy. J Hum Hypertens 2004
  6. doi:10.1038/sj.jhh.1001716 PMid:15014539 6. Takiuchi S, Rakugi H, Fujii H, Kamide K, Horio T, Nakatani S, et al. Carotid intima-media thickness is correlated with impairment of coronary flow reserve in hypertensive patients without coronary artery disease. Hypertens Res 2003
  7. doi:10.1291/hypres.26.945 PMid:14717336 7. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man: Anatomic validation of the method. Circulation 1977
  8. PMid:138494 8. Fathi R, Marwick TH. Noninvasive tests of vascular function and structure: why and how to perform them. Am Heart J 2001
  9. doi:10.1067/mhj.2001.114972 PMid:11320355 9. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993
  10. 87(3 Suppl): II56-65. PMid:8443925 10. Touboul PJ, Labreuche J, Vicaut E, Belliard JP, Cohen S, Kownator S, et al. Country-based reference values and impact of cardiovascular risk factors on carotid intima-media thickness in a French population: The 'Paroi Artérielle et Risque Cardio-Vasculaire' (PARC) Study. Cerebrovasc Dis 2009
  11. doi:10.1159/000202013 PMid:19218802 11. Matsushima Y, Takase B, Uehata A, Kawano H, Yano K, Ohsuzu F, et al. Comparative predictive and diagnostic value of flow-mediated vasodilation in the brachial artery and intima-media thickness of the carotid artery for assessment of coronary artery disease severity. Int J Cardiol 2007
  12. doi:10.1016/j.ijcard.2006.04.063 PMid:17258333 12. Güllü H, Erdoğ