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Journals / Anadolu Kardiyoloji Dergisi / 2011 / Cilt: 11 - Sayı: 8

Yavaş koroner akımlı hastalarda artmış neopterin düzeyleri ve anjiyografik değişkenlerle birlikteliği: Gözlemsel bir çalışma

Increased neopterin levels and its association with angiographic variables in patients with slow coronary flow: an observational study

Ercan VAROL
Doğan ERDOĞAN
Recep SÜTÇÜ
Mehmet GÜLCAN
Firdevs AYLAK
Mehmet ÖZAYDIN
Abdullah DOĞAN
Pages
692–697
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Serum hs-CRP levels were significantly higher among patients with SCF when compared with control group (2.06±1.32 vs. 0.74±0.40 mg/L respectively; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Although various inflammatory markers have been studied in patients with slow coronary flow (SCF), serum neopterin levels have not been studied previously.
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Key Findings & Data:Methods: The study group consisted of 51 patients with SCF.
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Conclusion & Impact:Serum hs-CRP levels were significantly higher among patients with SCF when compared with control group (2.06±1.32 vs. 0.74±0.40 mg/L respectively; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Although various inflammatory markers have been studied in patients with slow coronary flow (SCF), serum neopterin levels have not been studied previously. We investigated the serum neopterin and high sensitivity C-reactive protein (hs-CRP) levels and the relationship between neopterin and hs-CRP levels and TIMI flow in patients with SCF. Methods: The study group consisted of 51 patients with SCF. An age and gender matched control group was composed of 40 subjects. Coronary flow rates of all patients and control subjects were documented by Thrombolysis in Myocardial Infarction (TIMI) frame count. We measured serum neopterin and hs-CRP levels at the same time in patients with SCF and control subjects in this cross-sectional observational study. Chi-square, Mann-Whitney U and unpaired t tests, Pearson correlation and linear regression analyses were used for statistical analysis. Results: The TIMI frame counts for all coronary arteries and the mean TIMI frame count were significantly higher in the SCF group than controls. Serum neopterin levels were significantly higher among patients with SCF when compared with control group (2.13±1.03 vs. 1.60±0.50 ng/ml; p=0.004). Serum hs-CRP levels were significantly higher among patients with SCF when compared with control group (2.06±1.32 vs. 0.74±0.40 mg/L respectively; p

Özet

Amaç: Her ne kadar yavaş koroner akım (YKA)’lı hastalarda çeşitli enflamasyon göstergeleri çalışılmış olsa da, serum neopterin seviyeleri çalışılmamıştır. Yavaş koroner akım (YKA)’lı hastalarda serum neopterin ve yüksek duyarlı C-reaktif protein (hs-CRP) düzeylerini ve serum neopterin ve hs-CRP düzeyleriyle TIMI kare sayısı arasındaki ilişkiyi araştırdık. Yöntemler: Çalışma grubu 52 YKA hastasından, yaş ve cinsiyet açısından eşitlenmiş kontrol grubu 40 kişiden oluşmaktaydı. Hastaların ve kontrol grubunun koroner akım hızları (Thrombolysis In Myocardial Infarction) TIMI kare sayısı yöntemi ile ölçüldü. Bu enine-kesitli gözlemsel çalışmada, YKA ve kontrol grubunda serum neopterin ve hs-CRP düzeylerini ölçtük. İstatistiksel analizde Ki-kare, Mann-Whitney U ve esleştirilmemiş t testleri, Pearson korelasyon ve doğrusal regresyon analizleri kullanıldı. Bulgular: Bütün koroner arterlerin TIMI kare sayıları ve ortalama TIMI kare sayısı YKA hastalarında normal koroner arter grubundan daha yüksekti. Serum neopterin düzeyi YKA hastalarında kontrol grubundan daha yüksekti (2.13±1.03’e karşın 1.60±0.50 ng/ml sırasıyla; p=0.004). Serum hs-CRP düzeyi YKA hastalarında kontrol grubundan daha yüksekti (2.06±1.32’e karşın 0.74±0.40 mg/L sırasıyla; p

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Cite This Article

VAROL, E., ERDOĞAN, D., SÜTÇÜ, R., GÜLCAN, M., AYLAK, F., ÖZAYDIN, M., DOĞAN, A. (2022). Yavaş koroner akımlı hastalarda artmış neopterin düzeyleri ve anjiyografik değişkenlerle birlikteliği: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 11 - Sayı: 8, 692–697. https://ajindex.com/articles/436770

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