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Journals / Anadolu Kardiyoloji Dergisi / 2010 / Cilt: 10 - Sayı: 5

Akut miyokart enfarktüsünün sirkadiyen ritmine statin tedavisinin etkisi

Influence of statin therapy on circadian variation of acute myocardial infarction

Mustafa KARABACAK
Doğan ERDOĞAN
Ercan VAROL
Mehmet ÖZAYDIN
Abdullah DOĞAN
Yasin TÜRKER
Pages
429–433
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: In all study participants, the highest incidence of AMI was between 6.00 and 12.00; the odds ratio was 1.34 (95% CI 1.20 to 1.46, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Strong evidence has suggested that there is a circadian periodicity of acute coronary event.
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Key Findings & Data:Beta-blockers, aspirin and angiotensin-converting enzyme inhibitors decrease the rate of acute myocardial infarction (AMI) and blunt the peak incidence in the morning.
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Conclusion & Impact:Results: In all study participants, the highest incidence of AMI was between 6.00 and 12.00; the odds ratio was 1.34 (95% CI 1.20 to 1.46, p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Strong evidence has suggested that there is a circadian periodicity of acute coronary event. Beta-blockers, aspirin and angiotensin-converting enzyme inhibitors decrease the rate of acute myocardial infarction (AMI) and blunt the peak incidence in the morning. However, such effect has not been evaluated for statins. Accordingly, the present study aimed to evaluate the influence of statin therapy on circadian variation of AMI. Methods: This retrospective study consisted of 451 consecutive patients with acute ST segment elevation AMI. The patients were divided into two group based on prior statin usage. In statistical analysis t test, Chi-square test and Mann Whitney U test were used for comparison of groups. We used harmonic regression models to evaluate the circadian variation of onset of MI symptoms in patients receiving statin and patients not receiving statin. Results: In all study participants, the highest incidence of AMI was between 6.00 and 12.00; the odds ratio was 1.34 (95% CI 1.20 to 1.46, p

Özet

Amaç: Akut koroner olaylarda sirkadiyen ritmin olduğunu gösteren kuvvetli kanıtlar vardır. Beta-blokerler, aspirin ve anjiyotensin dönüştürücü enzim inhibitörlerinin akut miyokart infarktüs (AMİ) oranını ve sabah görülme sıklığını azaltmışlardır. Ancak, bu etkiler statinlerde araştırılmamıştır. Bu nedenle, bu çalışmada statin tedavisinin AMİ sirkadiyen ritmine etkisini araştırmayı amaçladık. Yöntemler: Dört yüz elli bir ardışık ST segment yükselmeli AMİ hastası retrospektif çalışmaya kabul edildi. Hastalar, önceden statin kullanmalarına göre iki gruba ayrıldılar. İstatistiksel analizde gruplar arası karşılaştırmalarda t testi, Ki-kare testi ve Mann-Whitney U testi kullanıldı. Statin kullanan ve kullanmayan AMİ hastalarının semptom başlangıç sirkadiyen ritmini değerlendirmede harmonik regresyon modeli kullanıldı. Bulgular: Tüm hastalar değerlendirildiğinde en yüksek AMİ sıklığı 06:00 ile 12:00 arası görüldü [%95 güven aralığında tahmini olasılık oranı=1.34 (1.20-1.46), p

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Cite This Article

KARABACAK, M., ERDOĞAN, D., VAROL, E., ÖZAYDIN, M., DOĞAN, A., TÜRKER, Y. (2022). Akut miyokart enfarktüsünün sirkadiyen ritmine statin tedavisinin etkisi. Anadolu Kardiyoloji Dergisi, Cilt: 10 - Sayı: 5, 429–433. https://ajindex.com/articles/436738

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