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Journals / Anadolu Kardiyoloji Dergisi / 2010 / Cilt: 10 - Sayı: 5

Fibrinolitik tedavi alan hastalarda homosistein düzeyleri ile enfarktüsle ilişkili arterin açıklığı ve akım hızının ilişkisi

Relation of homocysteine levels with patency and flow rate of infarct related artery in patients receiving fibrinolytic therapy

Hüseyin AYHAN
Telat KELEŞ
Tahir DURMAZ
Murat AKÇAY
Ekrem YETER
Akar Nihal BAYRAM
Engin BOZKURT
Pages
410–415
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In addition, we found a significant positive correlation between CTFC and plasma homocysteine levels (r=0.415; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective:Elevated homocysteine levels induce a hypercoagulable state and make the clot more resistant to fibrinolysis.
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Key Findings & Data:Methods: Sixty-one patients who received fibrinolytic therapy for a first ST elevation myocardial infarction (STEMI) within 12 hours of chest pain were included.
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Conclusion & Impact:In addition, we found a significant positive correlation between CTFC and plasma homocysteine levels (r=0.415; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective:Elevated homocysteine levels induce a hypercoagulable state and make the clot more resistant to fibrinolysis. In this prospective observational study, we investigated the influence of homocysteine levels on infarct-related artery (IRA) patency and flow as determined with regard to thrombolysis in myocardial infraction (TIMI) flow grade and corrected TIMI frame count (CTFC). Methods: Sixty-one patients who received fibrinolytic therapy for a first ST elevation myocardial infarction (STEMI) within 12 hours of chest pain were included. Coronary angiography was performed according to the Judkins technique within 72 hours after fibrinolytic therapy. Total plasma homocysteine level was determined by the high-performance liquid chromatography method with fluorescence detection. Statistical analysis was performed using Chi-square, Student’s t and Pearson correlation tests. Logistic regression analysis was used to determine the predictors of IRA occlusion. Results: Of the 61 patients, 22 (36.1%) had an occluded IRA (group 1), 39 (63.9%) had a patent IRA (group 2). Mean plasma homocysteine levels were found to be significantly higher in the group 1 compared to the group 2 (18.5±9.6 µmol/L vs 14.3±5 µmol/L, p=0.04). In addition, we found a significant positive correlation between CTFC and plasma homocysteine levels (r=0.415; p

Özet

Amaç:Yüksek homosistein düzeyleri mevcut pıhtıyı fibrinolize daha dirençli hale getirmektedir. Bu prospektif gözlemsel çalışmada, homosistein düzeylerinin, TIMI (thrombolysis in myocardial infarction) akım derecesi ve TIMI kare sayısına göre değerlendirilen enfarktüs ile ilişkili arter (EİA) açıklık ve akım hızı üzerine etkisini araştırdık.Yöntemler: ST yükselmeli miyokart enfarktüsü nedeniyle, göğüs ağrısının ilk 12 saati içinde fibrinolitik tedavi alan 61 hasta çalışmaya alındı. Fibrinolitik tedavi sonrası 72 saat içinde Judkins tekniği ile koroner anjiyografi yapıldı. Total plazma homosistein düzeyi flörosan saptama ile yüksek performanslı likit kromatografi metodu ile belirlendi. İstatistiksel analiz Ki-kare, Student t test, Pearson korelasyon testi kullanılarak yapıldı. EİA oklüzyonu öngördürücülerinin belirlemesinde lojistik regresyon analizi kullanıldı. Bulgular: Çalışmaya alınan 61 hastanın 22'sinde (%36.1) EİA tıkalı (grup 1), 39'unda (%63.9) EİA açık (grup 2) saptandı. Ortalama plazma homosistein düzeyleri grup 1 de grup 2 ile kıyaslandığında daha yüksekti (18.5±9.6 µmol/L’ye karşın 14.3±5 µmol/L, p=0.04). Ayrıca düzeltilmiş TIMI kare sayısıyla plazma homosistein düzeyleri arasında anlamlı bir pozitif korelasyon vardı (r=0.415; p

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Cite This Article

AYHAN, H., KELEŞ, T., DURMAZ, T., AKÇAY, M., YETER, E., BAYRAM, A. N., BOZKURT, E. (2022). Fibrinolitik tedavi alan hastalarda homosistein düzeyleri ile enfarktüsle ilişkili arterin açıklığı ve akım hızının ilişkisi. Anadolu Kardiyoloji Dergisi, Cilt: 10 - Sayı: 5, 410–415. https://ajindex.com/articles/436737

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