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Journals / Anadolu Kardiyoloji Dergisi / 2010 / Cilt: 10 - Sayı: 5

Down sendromlu çocuklarda konjenital kalp hastalıkları ve tiroid anormalliklerinin değerlendirilmesi

Evaluation of congenital heart diseases and thyroid abnormalities in children with Down syndrome

İbrahim KESER
Fırat KARDELEN
Ercan MIHÇI
Erdal EREN
Sema AKÇURİN
Gayaz AKÇURİN
Halil ERTUĞ
Pages
440–445
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: It was found that 136 (72.73%) patients with DS had CHD.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Congenital heart disease (CHD) associated with thyroid disease has been reported in Down syndrome (DS).
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Key Findings & Data:Methods: This retrospective study included 187 children with DS between August 1993- December 2005.
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Conclusion & Impact:Results: It was found that 136 (72.73%) patients with DS had CHD.
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Congenital heart disease (CHD) associated with thyroid disease has been reported in Down syndrome (DS). The purpose of this work was to assess abnormalities of the thyroid in relation to the frequency and type of CHD on admission among children with DS. Methods: This retrospective study included 187 children with DS between August 1993- December 2005. Karyotype analysis, thyroid function tests and echocardiographic studies were performed in all children with DS. If necessary, hemodynamic study by catheterization was carried out. Thyrotropin releasing hormone (TRH) stimulation test was performed in patients having elevated thyroid stimulating hormone (TSH) level. Statistical analyses were performed using Chi-square, “t” test for independent samples or Mann-Whitney U test. Results: It was found that 136 (72.73%) patients with DS had CHD. The age difference at the time of admission was statistically significant for these two groups (p

Özet

Amaç: Down sendromunda (DS), konjenital kalp hastalığı (KKH) ve tiroid hastalığı (TH) birlikteliği bildirilmiştir. Bu çalışmanın amacı, başvuru sırasında DS’lu çocuklardaki konjenital kalp hastalığının tipi ve sıklığı ile tiroid bozukluğu arasındaki ilişkiyi belirlemektir. Yöntemler: Bu retrospektif çalışma, Ağustos 1993 ile Aralık 2005 arasındaki DS’lu 187 çocuğu içermekteydi. DS’lu tüm hastalara karyotip analizi, tiroid fonksiyon testi ve ekokardiyografik çalışmalar yapıldı. Gereken hastalara kalp kateterizasyonu uygulanarak hemodinamik çalışmalar yapıldı. Tiroidi uyarıcı hormon (TSH) düzeyi yüksek olanlara tirotropin salgılatıcı hormon uyarı testi yapıldı. İstatistiksel analizlerde Ki-kare, bağımsız örneklem “t” veya Mann-Whitney U testleri kullanıldı. Bulgular: DS’lu 136 (%72.73) hasta konjenital kalp hastalığına sahipti. KKH’lığı olan ve olmayan DS’lu hastalardan oluşan iki grup arasında, başvuru zamanlarındaki yaşlara göre istatistiksel anlamlılık (p

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Cite This Article

KESER, İ., KARDELEN, F., MIHÇI, E., EREN, E., AKÇURİN, S., AKÇURİN, G., ERTUĞ, H. (2022). Down sendromlu çocuklarda konjenital kalp hastalıkları ve tiroid anormalliklerinin değerlendirilmesi. Anadolu Kardiyoloji Dergisi, Cilt: 10 - Sayı: 5, 440–445. https://ajindex.com/articles/436719

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