AI Summary & Key Takeaways
AI InsightObjective: We aimed to evaluate serum adiponectin and C-reactive protein (CRP) levels in the different groups of patients with angiographically defined coronary artery disease (CAD).Methods: Overall 100 patients (80 males, 20 females) with CAD (≥ 50% stenosis) and 45 controls (25 males, 20 females) with normal coronary arteries were included in this cross-sectional observational study.
📌 3 Key Takeaways
Abstract
Objective: We aimed to evaluate serum adiponectin and C-reactive protein (CRP) levels in the different groups of patients with angiographically defined coronary artery disease (CAD).Methods: Overall 100 patients (80 males, 20 females) with CAD (≥ 50% stenosis) and 45 controls (25 males, 20 females) with normal coronary arteries were included in this cross-sectional observational study. Gensini score was used for evaluation of the severity of coronary lesions on the angiogram. A relationship between Gensini score and serum CRP and adiponectin levels was evaluated by a logistic regression analysis.Results: Mean age of the patients (60.5±10.2 years) was significantly higher than of the controls (55.6±10.4 years, p=0.01). While serum adiponectin levels in CAD patients (2.1±1.2 µmg/dl) were significantly lower than in the controls (3.3±1.8 µmg/dl, p=0.01); serum CRP levels of the patients (2.8±1.5 mg/dl) were significantly higher than of the controls (0.9±0.4 mg/dl). Serum adiponectin and CRP levels were not significantly different between the CAD subgroups (p>0.05). Gensini score was related with serum CRP (odds ratio: 0.98, 95% CI: 1.05-1.35, p=0.01) and adiponectin levels (odds ratio: 1.15, 95% CI: 1.10-1.25, p=0.01) by a logistic regression analysis. Conclusion: While serum CRP levels are increased in CAD patients comparing with the controls; serum adiponectin levels are decreased significantly. Serum CRP and adiponectin levels are related to coronary lesions severity on the angiogram.
Özet
Amaç: Anjiyografik tanılı koroner arter hastalığı (KAH) olan hasta gruplarında, serum adiponektin ve C-reaktif protein (CRP) düzeylerinin değerlendirilmesini amaçladık.Yöntemler: KAH (≥ %50 darlık) saptanan 100 hasta (80 erkek, 20 kadın) ve koronerleri normal bulunan 45 kontrol (25 erkek, 20 kadın) bu enine –kesitli gözlemsel çalışmaya alındı. Anjiyogramda koroner lezyon şiddetini belirlemede Gensini skoru kullanıldı. Gensini skorunun serum CRP ve adiponektin düzeyleri ile ilişkisi, lojistik regresyon analizi ile değerlendirildi.Bulgular: Hastaların ortalama yaşı (60.5±10.2 yıl), kontrol grubundan (55.6±10.4 yıl) anlamlı olarak daha yüksekti (p=0.01). Hastalarda serum adiponektin düzeyleri (2.1±1.2 µmg/dl), kontrollerden (3.3±1.8 µmg/dl) anlamlı olarak daha düşükken (p=0.01); CRP (2.8±1.5 mg/dl) düzeyleri, kontrollerden (0.9±0.4 mg/dl) daha yüksekti (p=0.001). Serum adiponektin ve CRP düzeyleri, koroner lezyonlu damar grupları arasında anlamlı bir fark oluşturmadı (p>0.05). Gensini skoru, lojistik regresyon analizi ile, serum CRP (olasılık oranı: 0.98, %95 güven aralığı 1.05-1.35, p=0.01) ve adiponektin (olasılık oranı: 1.15, %95 güven aralığı 1.10-1.25, p=0.01) düzeyleri ile ilişkili bulundu.Sonuç: KAH olanlarda, kontroller ile kıyaslandığında, serum CRP düzeyleri artmakta iken; adiponektin düzeyleri anlamlı olarak azalmaktadır. Serum CRP ve adiponektin düzeyleri, anjiyogramda koroner lezyon şiddeti ile ilişkilidir.