SavedAdd your journal

Journals / Anadolu Kardiyoloji Dergisi / 2011 / Cilt: 11 - Sayı: 8

Kadınlarda oral kontraseptif tedavisinin homosistein ve C-reaktif protein düzeyleri üzerine etkisi: Gözlemsel bir çalışma

Effect of oral contraceptive therapy on homocysteine and C-reactive protein levels in women: an observational study

Vajihe NOROUZİ
Morteza SEİFİ
Soudabeh FALLAH
Mohsen KORANİ
Ali SAMADİKUCHAKSARAEİ
Pages
698–702
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The results showed that the homocysteine (13.268±3.475 vs. 7.288±2.621 μmol/L) and CRP (5863.0±1349.5 vs. 1138.3±691.12 ng/ml) levels were significantly higher in women receiving OCP in comparison with the control group (p=0.027 and p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Increased levels of homocysteine and C-reactive protein (CRP) are considered as independent risk factors for atherosclerosis.
📊
Key Findings & Data:Methods: We conducted an observational cross-sectional analysis of 90 healthy, non-obese women (mean age 25 years and body-mass index 22 kg/m2).
💡
Conclusion & Impact:Results: The results showed that the homocysteine (13.268±3.475 vs. 7.288±2.621 μmol/L) and CRP (5863.0±1349.5 vs. 1138.3±691.12 ng/ml) levels were significantly higher in women receiving OCP in comparison with the control group (p=0.027 and p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Increased levels of homocysteine and C-reactive protein (CRP) are considered as independent risk factors for atherosclerosis. As the level of these factors is affected by sex hormones, a population-based assessment of their changes following oral contraceptive therapy is needed to avoid the side effects that might arise of these variations. To this aim, the present study was to investigate the effect of combined oral contraceptive (OCP) on CRP and homocysteine levels among young healthy women. Methods: We conducted an observational cross-sectional analysis of 90 healthy, non-obese women (mean age 25 years and body-mass index 22 kg/m2). Forty-five healthy women on OCP and 45 healthy controls were studied for CRP and homocysteine levels by enzyme-linked immunosorbent assay (ELISA). Unpaired t test and Chi-square test were used for comparison of variables between oral contraceptive users and non-oral contraceptive users. Results: The results showed that the homocysteine (13.268±3.475 vs. 7.288±2.621 μmol/L) and CRP (5863.0±1349.5 vs. 1138.3±691.12 ng/ml) levels were significantly higher in women receiving OCP in comparison with the control group (p=0.027 and p

Özet

Amaç: Artmış homosistein ve C-reaktif protein (CRP) düzeyleri ateroskleroz için bağımsız risk faktörü olarak kabul edilmektedir. Bu faktörlerin düzeyi, cinsiyet hormonları, oral kontraseptif tedavisi bu varyasyonlar ortaya çıkabilecek yan etkileri önlemek için gerekli değişiklikleri nüfus tabanlı bir değerlendirme de etkilenir. Bu çalışmanın amacı, genç sağlıklı kadınlarda kombine oral kontraseptif ilaçların (OCP) CRP ve homosistein üzerine etkilerini araştırmaktır. Yöntemler: Obez olmayan, 90 sağlıklı kadında (Ortalama yaşları 25 ve vücut kitle indeksi 22 kg/m2) gözlemsel kesitsel analiz yapıldı. Kırk beş OCP kullanan sağlıklı ve kontrol grubundaki kadınlarda ELIZA tekniği ile CRP ve homosistein düzeyleri incelenmiştir. Eşleştirilmemiş t-testi ve Ki-kare testi, oral kontraseptif kullanıcıları ve non-oral kontraseptif kullanıcıların arasındaki değişkenlerin karşılaştırılması için kullanıldı. Bulgular: Bu sonuçlar, homosistein (13.268±3.475’e karşı 7.288±2.621 μmol/L) ve CRP (5863.0±1349.5’e karşı 1138.3±691.12 ng/ml) düzeyleri kontrol grubu ile karşılaştırıldığında (p=0.027 ve p

🔖

Cite This Article

NOROUZİ, V., SEİFİ, M., FALLAH, S., KORANİ, M., SAMADİKUCHAKSARAEİ, A. (2022). Kadınlarda oral kontraseptif tedavisinin homosistein ve C-reaktif protein düzeyleri üzerine etkisi: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 11 - Sayı: 8, 698–702. https://ajindex.com/articles/436642

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Reuben DB, Palla SL, Hu P, Reboussin BA, Crandall C, Herrington DM, et al. Progestins affect mechanism of estrogen-induced C-reactive protein stimulation. Am J Med 2006; 119: 167
  2. Krivak TC, Zorn KK. Venous thromboembolism in obstetrics and gynecology. Obstet Gynecol 2007; 109: 761-77
  3. Cauci S, Di Santolo M, Culhane JF, Stel G, Gonano F, Guaschino S. Effects of third- generation oral contraceptives on high-sensitivity C-reactive protein and homocysteine in young women. Obstet Gynecol 2008; 111: 857-64
  4. Ridker PM, Silvertown JD. Inflammation, C-reactive protein, and atherothrombosis.J Periodontol 2008; 79(8 Suppl): 1544-51
  5. Yan J, Liao JK, Wang D. Elevated homocysteine and C-reactive protein levels independently predict worsening prognosis after stroke in Chinese patients. J Huazhong Univ Sci Technolog Med Sci 2010; 30: 643-7
  6. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836-43
  7. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-54
  8. Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-74
  9. Raitakari M, Mansikkaniemi K, Marniemi J, Viikari JS, Raitakari OT. Distribution and determinants of serum high-sensitive C-reactive protein in a population of young adults: The Cardiovascular Risk in Young Finns Study. J Intern Med 2005; 258: 428-34. 10. de Ferranti SD, Gauvreau K, Ludwig DS, Newburger JW, Rifai N. Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys. Clin Chem 2006; 52: 1325-30
  10. Casabellata G, Di Santolo M, Banfi G, Stel G, Gonano F, Cauci S. Evaluation of iron deficiency in young women in relation to oral contraceptive use. Contraception 2007; 76: 200-7
  11. Frantzen F, Faaren AL, Alfheim I, Nordhei AK. Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem 1998; 44: 311-6
  12. Martini MC, Dancisak BB, Haggans CJ, Thomas W, Slavin JL. Effects of soy intake on sex hormone metabolism in premenopausal women. Nutr Cancer 1999; 34: 133-9
  13. Hak AE, Polderman KH, Westendorf IC, Jakob C, Hoftman A, Witterman JC, et al. Increased plasma homocysteine after menopause. Atherosclerosis 2000: 149: 163-8
  14. Ridker PM. Evaluating novel cardiovascular risk factors: can be we