Journals / Anadolu Kardiyoloji Dergisi / 2011 / Cilt: 11 - Sayı: 1

Ateroskleroz ve asetilsalisilik asit gastrik ve duodenal ülser kanaması için bağımsız risk faktörleridir

Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer

Pages
53–56
Publication Date
2022-10-10
DOI
—
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Conclusion: Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer.

📌 3 Key Takeaways

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Objective & Hypothesis:Risk factors for hemorrhage due to gastric and/or duodenal ulcer in patients diagnosed by upper gastrointestinal (GI) endoscopy were investigated in the present study.
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Key Findings & Data:Methods: Medical records of 350 patients (226 males, 124 females) diagnosed as duodenal or gastric ulcers by GI endoscopy in the gastroenterology clinic were scanned retrospectively.
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Conclusion & Impact:Conclusion: Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Risk factors for hemorrhage due to gastric and/or duodenal ulcer in patients diagnosed by upper gastrointestinal (GI) endoscopy were investigated in the present study. Methods: Medical records of 350 patients (226 males, 124 females) diagnosed as duodenal or gastric ulcers by GI endoscopy in the gastroenterology clinic were scanned retrospectively. Upper GI hemorrhage was detected in 92 patients by upper endoscopic examination. The medical history of non-steroidal anti-inflammatory drugs (NSAIDs) or acetylsalicylic acid (ASA) usage and the presence of coronary artery disease (CAD) were investigated in all patients with or without hemorrhage. Results were evaluated by Chi-square test and logistic regression analysis. Results: The mean age of the patients was 50.4±15.7 years (range: 25 to 82 years). Hemorrhage due to gastric or duodenal ulcer was identified in 92 patients (26%). Mean age was 64.6±11.4 years in patients with hemorrhage and 45.7±13.9 years in patients without hemorrhage. ASA usage was more common than NSAID in patients with ulcer hemorrhage (NSAID usage n=35 (40%); ASA usage n=51 (60%); p=0.035). Hemorrhage was reported in 20% of the females and in 28% of the males who have ulcer (p=0.055). Risk factors for hemorrhage were CAD (OR:24.75, 95% CI=1.6-96.7, p=0.001), ASA usage (OR:9.76, 95% CI=2.1-37.5, p=0.021), NSAID usage (OR: 4.72, 95%CI=1.1-16.5, p=0.032), age (OR: 11.59, 95% CI= 2.7-12.1, p=0.001), and male gender (OR: 2.56, 95% CI= 0.8, 9.6, p=0.052). Conclusion: Advanced age, atherosclerosis, male gender and NSAID administration (particularly aspirin) are the major risk factors of upper GI hemorrhage in patients with gastric and/or duodenal ulcer.

Özet

Üst gastrointestinal (Gİ) endoskopide gastrik ve/veya duodenal ülser saptanan vakalarda ülser kanaması için risk faktörleri araştırıldı. Yöntemler: Üst Gİ endoskopisinde duodenum ve gastrik ülser saptanan 350 vakanın (226 Erkek, 124 Kadın) dosyalarından retrospektif analiz yapıldı. İncelenen 92 vakada endoskopi sırasında Gİ kanama saptanmıştı. Kanaması olan ve olmayan hastaların tümünde nonsteroidal antienflamatuvar ilaç (NSAID) ve asetil salisilik asit (ASA) kullanımı ile koroner arter hastalığı (KAH) varlığı araştırıldı. Sonuçlar Ki-kare testi ve lojistik regresyon analizi ile değerlendirildi. Bulgular: Vakaların yaş ortalaması 50.4±15.7 (25- 82) yıl idi. Doksan iki vakada (%26) gastrik veya duodenal ülsere bağlı kanama görüldü. Kanamalı hastalarda yaş ortalaması 64.6±11.4/ yıl, kanama olmayanlarda 45.7±13.9/yıl idi. Ülser kanaması olan vakalarda ASA kullanımı daha fazlaydı (NSAID, n=35 (%40); ASA, n=51 (%60); p=0.035). Ülseri olan kadınların %20’sinde kanama görülürken, erkeklerin %28’inde kanama görüldü (p=0.055). Kanama riski KAH’lı vakalarda (OR:24.75, %95 güven aralığı (GA)=1.6-96.7, p=0.001), ASA (OR:9.76, %95 GA=2.1-37.5, p=0.021), NSAID (OR:4.72, %95 GA=1.1-16.5 p=0.032), yaş (OR:11.59, %95 GA=2.7-12.1, p=0.001), erkek cinsiyet için (OR:2.56, %95 GA=0.8, 9.6, p=0.052) olarak belirlendi. Sonuç: İleri yaş, ateroskleroz, erkek cinsiyet ve NSAİD (özellikle aspirin) kullanımı gastrik ve/veya duodenal ülserli hastalarda üst Gİ kanaması bakımından majör risk faktörleridir.

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Cite This Article

SANDIKÇI, M., AKKIZ, H., COŞAR, A., ÖZDİL, B. (2022). Ateroskleroz ve asetilsalisilik asit gastrik ve duodenal ülser kanaması için bağımsız risk faktörleridir. Anadolu Kardiyoloji Dergisi, Cilt: 11 - Sayı: 1, 53–56. https://ajindex.com/articles/436569

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