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Journals / Anadolu Kardiyoloji Dergisi / 2012 / Cilt: 12 - Sayı: 7

Hiperglisemi diyabetik tavşanlarda atriyal interstisiyel fibrosis, iyonik remodeling ve atriyal fibrilasyon duyarlılığını arttırmaktadır

Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits

Huaying FU
Wansong YANG
Lijun CHENG
Guangping LI
Tong LIU
Changle LIU
Jian LI
Pages
543–550
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Compared with control group, electrophysiological studies showed IACT was prolonged (37.91±6.81 vs. 27.43±1.63ms, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study was to investigate the effects of hyperglycemia on atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation (AF) in alloxan-induced diabetic rabbits.
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Key Findings & Data:Methods: Sixty Japanese rabbits were randomly assigned to alloxan-induced diabetic group (n=30) and control group (n=30).
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Conclusion & Impact:Results: Compared with control group, electrophysiological studies showed IACT was prolonged (37.91±6.81 vs. 27.43±1.63ms, p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of this study was to investigate the effects of hyperglycemia on atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation (AF) in alloxan-induced diabetic rabbits. Methods: Sixty Japanese rabbits were randomly assigned to alloxan-induced diabetic group (n=30) and control group (n=30). Ten rabbits in each group were respectively used to electrophysiological and histological study, patch-clamp study and Western blotting analysis. Langendorff perfusion was used to record inter-atrial conduction time (IACT), atrial effective refractory period (AERP) and dispersion (AERPD) and vulnerability to AF. Histological study was measured by Sirius-red stain. Patch-clamp technique was used to measure action potential duration (APD) and atrial ionic currents (INa and ICaL). Western blotting was applied to assess atrial protein expression of transforming growth factor beta 1 (TGFβ1). Results: Compared with control group, electrophysiological studies showed IACT was prolonged (37.91±6.81 vs. 27.43±1.63ms, p

Özet

Amaç: Bu çalışmanın amacı, alloksan etkisi ile oluşturulmuş diyabetik tavşanlarda atriyal intersitisyel fibrosis, iyonik remodeling ve atriyal fibrilasyona (AF) duyarlılığa hipergliseminin etkisini araştırmaktır. Yöntemler: Altmış Japon tavşanı alloksan etkisi ile oluşturulmuş diyabetik grup (n=30) ve kontrol grup (n=30) olarak gelişi güzel belirlendi. Herbir grupta 10 tavşan sırasıyla elektrofizyolojik ve histolojik çalışma, “patch-klemp” çalışma ve Western blotting analizi kullanıldı. İnter-atriyal iletim zamanı (İAİZ), atriyal efektif refraktör dönem (AERP), dağılım (AERD) ve AF duyarlılığını kaydetmek için Langendorff perfüzyonu kullanıldı. Histolojik çalışma Sirius-kırmızı boyama ile değerlendirildi. Aksiyon potansiyel süresi (APS) and atriyal iyonik akımları (INa and ICaL) ölçmek için “patch-klemp” tekniği kullanıldı. Dönüştürücü büyüme faktörü beta 1 (DBFβ1)’in atriyal protein ekspresyonunu değerlendirmek için Western blotting uygulandı. Bulgular: Kontrol grubu ile karşılaştırıldığında, diyabetik grupta elektrofizyolojik çalışmalar İAİZ’nın uzadığını (37.91±6.81 ve 27.43±1.63 ms, p

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Cite This Article

FU, H., YANG, W., CHENG, L., LI, G., LIU, T., LIU, C., LI, J. (2022). Hiperglisemi diyabetik tavşanlarda atriyal interstisiyel fibrosis, iyonik remodeling ve atriyal fibrilasyon duyarlılığını arttırmaktadır. Anadolu Kardiyoloji Dergisi, Cilt: 12 - Sayı: 7, 543–550. https://ajindex.com/articles/436484

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