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Journals / Anadolu Kardiyoloji Dergisi / 2012 / Cilt: 12 - Sayı: 7

Kalitatif immünkromotografik yöntemle bakılan kalp tipi serbest yağ asidi bağlayıcı protein in minör miyokardiyal hasarla seyreden ST yükselmesiz akut koroner sendromlardaki tanısal değeri

Diagnostic value of heart-type fatty acid binding protein determined by the rapid qualitative chromatographic immunoassay method for the detection of minor myocardial damage in patients presenting with non- ST elevation acute coronary syndrome

Yüksel ÇAVUŞOĞLU
Bülent GÖRENEK
Necmi ATA
Alparslan BİRDANE
Canan DEMİRÜSTÜ
Bülent GÖK
Pages
584–590
Publication Date
2022-10-10
DOI
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Results: The sensitivity of the H-FABP was significantly higher for NSTEMI-ACS than for MMD-ACS (44.7% vs 0%, p3-fold increase in cTnI than those with

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Objective & Hypothesis:Objective: The aim of this prospective study was to evaluate the diagnostic value of heart-type fatty acid binding protein (H-FABP) determined by qualitative immunoassay method for the detection of minor myocardial damage (MMD) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).
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Key Findings & Data:Methods: The study consisted of 62 patients with NSTE-ACS.
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Conclusion & Impact:Results: The sensitivity of the H-FABP was significantly higher for NSTEMI-ACS than for MMD-ACS (44.7% vs 0%, p3-fold increase in cTnI than those with
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this prospective study was to evaluate the diagnostic value of heart-type fatty acid binding protein (H-FABP) determined by qualitative immunoassay method for the detection of minor myocardial damage (MMD) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). Methods: The study consisted of 62 patients with NSTE-ACS. Cardiac troponin I (cTnI) and creatine kinase MB isoenzyme (CK-MB) values were measured at arrival. Myoglobin and H-FABP were obtained if cTnI level was found to be elevated. A control group included 20 subjects with normal cTnI and CK-MB values. H-FABP was determined by a rapid qualitative immunochromatographic test. Patients were classified as MMDACS group if they had abnormal cTnI and normal CK-MB (n=24) and as NSTEMI-ACS group if they had elevated both cTnI and CK-MB (n=38). The diagnostic accuracy of H-FABP for minor myocardial damage was determined using ROC analysis. Results: The sensitivity of the H-FABP was significantly higher for NSTEMI-ACS than for MMD-ACS (44.7% vs 0%, p3-fold increase in cTnI than those with

Özet

Amaç: Bu prospektif çalışmanın amacı, yatak başı kalitatif yöntemle belirlenen kalp tipi serbest yağ aside bağlayıcı proteinin (H-FABP), minör miyokardiyal hasarla (MMH) seyreden ST yükselmesiz akut koroner sendromlardaki (NSTE-ACS) tanısal değerini incelemekti. Yöntemler: Çalışmaya NSTE-ACSli 62 olgu alındı. Hastaneye kabulde kardiyak troponin I (cTnI) ve kreatin kinaz MB izoenzim (CK-MB) düzeyleri ölçüldü. cTnI yüksek bulunanlarda, H-FABP ve miyoglobin düzeyleri bakıldı. Ayrıca cTnI ve CK-MB düzeyleri normal olan 20 olguluk kontrol grubu oluşturuldu. H-FABP, yatak başı kalitatif immünkromotografik yöntemle bakıldı. On iki saatlik takipte cTnI ve CK-MB düzeyleri yüksek bulunanlar NSTEMI-ACS (38 olgu) ve cTnI yüksek ancak CK-MB normal bulunanlar MMH-ACS (24 olgu) olarak tanımlandı. H-FABPnın minör miyokart hasarı için tanısal doğruluğu ROC analizi ile değerlendirildi. Bulgular: H-FABPnin duyarlılığı, NSTEMI-ACSde MMH-ACSden anlamlı yüksek (%44.7 ve %0, p

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Cite This Article

ÇAVUŞOĞLU, Y., GÖRENEK, B., ATA, N., BİRDANE, A., DEMİRÜSTÜ, C., GÖK, B. (2022). Kalitatif immünkromotografik yöntemle bakılan kalp tipi serbest yağ asidi bağlayıcı protein in minör miyokardiyal hasarla seyreden ST yükselmesiz akut koroner sendromlardaki tanısal değeri. Anadolu Kardiyoloji Dergisi, Cilt: 12 - Sayı: 7, 584–590. https://ajindex.com/articles/436395

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