Journals / Anadolu Kardiyoloji Dergisi / 2013 / Cilt: 13 - Sayı: 2

ST-yükselmesi olmayan akut miyokart enfarktüsünün erken değerlendirmesinde oksidatif stres ve enflamasyonun rolü: Gözlemsel bir çalışma

The role of oxidative stress and inflammation in the early evaluation of acute non-ST-elevation myocardial infarction: An observational study

Pages
131–136
Publication Date
2022-10-10
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to assess the role of oxidative stress (OS) and inflammation in the early evaluation of initial acute non -ST -elevation myocar- dial infarction (NSTEMI) compared with unstable angina pectoris (USAP).
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Key Findings & Data:Methods: Forty-seven (54%) patients with NSTEMI and 40 (46%) with (USAP) were included in this cross-section observational study.
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Conclusion & Impact:Results: Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to assess the role of oxidative stress (OS) and inflammation in the early evaluation of initial acute non -ST -elevation myocar- dial infarction (NSTEMI) compared with unstable angina pectoris (USAP). Methods: Forty-seven (54%) patients with NSTEMI and 40 (46%) with (USAP) were included in this cross-section observational study. We assessed the oxidative stress and inflammation parameters. Statistical analysis was performed using Fisher’s exact test, Chi-square test, Mann-Whitney U test, Student’s t-test, and Pearson correlation analysis for assess the correlations between variables. Results: Plasma total oxidative stress (TOS) and OS index levels were significantly higher (p

Özet

Amaç: Kararsız angina pectoris (USAP) ile karşılaştırıldığında ST-elevasyonsuz miyokart enfarktüsünün (NSTEMI) başlangıç değerlendirmesinde oksidatif stres ve enflamasyonun rolünü belirlemeyi amaçladık. Yöntemler: Bu enine-kesitli gözlemsel çalışmaya NSTEMI bulunan 47 (%54) ve USAP bulunan 40 (%46) hasta dahil edildi. Çalışmamızda OS ve enflamasyon parametrelerini inceledik. İstatistiksel analizde Fischer’s tam testi, Ki- kare testi, Student’s t-testi, Mann-Whitney U testi ve değişken- ler arasındaki ilişkiyi göstermek için Pearson korelasyon analizi kullanıldı. Bulgular: NSTEMI olan olgularda, plazma total oksidatif stres (TOS) ve OS indeks düzeyleri belirgin olarak yüksek idi (her iki karşılaştırma için; p

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Cite This Article

GÖKDEMİR, M. T., TAŞKIN, A., KAYA, H., ALBAYRAK, L., KAYA, Z., SÖĞÜT, Ö. (2022). ST-yükselmesi olmayan akut miyokart enfarktüsünün erken değerlendirmesinde oksidatif stres ve enflamasyonun rolü: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 13 - Sayı: 2, 131–136. https://ajindex.com/articles/436152

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References (6)

  1. Ridker PM. Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view. Blood Coagul Fibrinolysis 1999; 10: 9-12
  2. Marchegiani F, Spazzafumo L, Cardelli M, Provinciali M, Lescai F, Franceschi C, et al. Paraoxonase-1 55 LL genotype is associated with no ST-elevation myocardial infarction and with high levels of myoglobin. J Lipids 2012; 2012: 601796
  3. Madamanchi NR, Vendrov A, Runge MS. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol 2005; 25: 29-38
  4. Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994; 344: 721-4. [CrossRef] 5. Halliwell B, Gutteridge JM. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet 1984; 1: 1396-7. [CrossRef] 6. Özdoğan K, Taşkın E, Dursun N. Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats. Anadolu Kardiyol Derg 2011; 1: 3-10
  5. Griendling KK, Fitzgerald GA. Oxidative stress and cardiovascular injury. Part: II: animal and human studies. Circulation 2003; 108: 2034-40. [CrossRef] 8. Heistad DD. Oxidative stress and vascular disease: 2005 Duff lecture. Arterioscler Thromb Vasc Biol 2006; 26: 689-95. [CrossRef] 9. Heistad DD, Wakisaka Y, Miller J, Chu Y, Pena-Silva R. Novel aspects of oxidative stress in cardiovascular diseases. Circ J 2009; 73: 201-7. [CrossRef] 10. Kukielka GL, Smith CW, Manning AM, Youker KA, Michael LH, Entman ML. Induction of interleukin-6 synthesis in the myocardium. Potential role in postreperfusion inflammatory injury. Circulation 1995; 92: 1866-75. [CrossRef] 11. von Knethen A, Callsen D, Brune B. Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression. J Immunol 1999; 163: 2858-66
  6. Georgiadou P Iliodromitis EK, Varounis C, Mavroidis M, Kolokathis F, Andreadou I, et al. Relationship between plasma osteopontin and oxidative stress in patients with coronary artery disease. Expert Opin Ther Targets 2008; 12: 917-20. [CrossRef] 13. Vassalle C, Pratali L, Boni C, Mercuri A, Ndreu R. An oxidative stress score as a combined measure of the pro-oxidant and anti- -oxidant counterparts in patients with coronary artery disease. Clin Biochem 2008; 41: 1162-7. [CrossRef] 14. Frossard M, Fuchs I, Leitner JM, Hsieh K, Vlcek M, Losert H, et al. Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation 2004; 110: 1392-7. [CrossRef] 15. Biasucci LM, V