Journals / Anadolu Kardiyoloji Dergisi / 2013 / Cilt: 13 - Sayı: 3

Kaşektik olmayan sistolik kalp yetmezlikli olgularda adiponektin, NT-pro-BNP ve sol ventrikül ejeksiyon fraksiyonu arasındaki ilişki: Gözlemsel bir çalışma

The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study

Pages
221–226
Publication Date
2022-10-10
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19±12.9 vs. 7.65±4.6 μg/mL; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF).
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Key Findings & Data:Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients.
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Conclusion & Impact:Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19±12.9 vs. 7.65±4.6 μg/mL; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF). Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients. The study was designed to inves- tigate the possible association of these markers in non-cachectic patients with newly diagnosed systolic heart failure. Methods: Fifty-seven systolic HF patients and 20 matched controls were enrolled in an observational cross-sectional study. Physical and echo- cardiographic examinations were performed and serum Adp, NT-proBNP tumor necrosis factor-alpha (TNF-α) levels were measured. Study , variables were compared between the groups. Correlation analyses were done and the diagnostic validity of the markers was compared with ROC analysis. Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19±12.9 vs. 7.65±4.6 μg/mL; p

Özet

Amaç: Kalp yetmezliği (KY) olgularında NT-pro-beyin natriüretik peptid'in (NT-proBNP) tanısal değeri bilinmektedir. Adiponektin (Adp) düzeyleri bu olgularda yükselmektedir, ancak tanısal değeri henüz belirsizdir. Çalışma, yeni tanı almış, kaşektik olmayan sistolik kalp yetmezlikli olgularda söz konusu serum göstergelerinin muhtemel ilişkisinin araştırılması için tasarlanmıştır. Yöntemler: Sistolik KY tanısı konan 57 olgu ile yaş-cinsiyet uyumlu 20 kontrol olgusu gözlemsel kesitsel çalışmaya dahil edildi. Fizik muayene ve ekokardiyografik değerlendirmenin yanı sıra serum Adp, NT-proBNP tümör nekrozis faktör-alfa (TNF-α) düzeyleri ölçüldü. Çalışma değişkenleri , gruplar arasında karşılaştırıldı. Korelasyon analizleri yapıldı ve göstergelerin tanısal geçerliliği ROC analizi ile karşılaştırıldı. Bulgular: Adp ve NT-proBNP düzeyleri KY grubunda anlamlı şekilde yüksek bulundu (sırasıyla 20.19±12.9’e karşılık 7.65±4.6 μg/mL; p

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Cite This Article

KIRILMAZ, B., TAMER, S. G., ALİOĞLU, E., TÜZÜN, N., TÜRK, U. Ö., ERCAN, E., TENGİZ, İ. (2022). Kaşektik olmayan sistolik kalp yetmezlikli olgularda adiponektin, NT-pro-BNP ve sol ventrikül ejeksiyon fraksiyonu arasındaki ilişki: Gözlemsel bir çalışma. Anadolu Kardiyoloji Dergisi, Cilt: 13 - Sayı: 3, 221–226. https://ajindex.com/articles/436134

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