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Journals / Akdeniz Tıp Dergisi / 2017 / Cilt: 3 - Sayı: 2

The relationship Between Plasma sTrAıL Level and Disease Activity in rheumatoid Arthritis

romatoid Artritte Plazma sTrAıL Düzeyi ile Hastalık Aktivitesi İlişkisi

Veli YAZISIZ
Ender TERZİOĞLU
Funda ERBASAN
Münevver KAHRAMAN
Pages
95–100
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings suggest that sTrAıL may have an important role in the pathogenesis of rheumatoid arthritis.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study was to investigate the plasma soluble tumour necrosis factor related apoptosis-inducing ligand (sTrAıL) level in rheumatoid arthritis (rA) and to evaluate the relationship between sTrAıL and disease activity.
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Key Findings & Data:Material and Methods: 19 rA patients, and as a control group 31 primary Sjogren's syndrome (pSS) patients and 24 healthy subjects were included in the study.
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Conclusion & Impact:These findings suggest that sTrAıL may have an important role in the pathogenesis of rheumatoid arthritis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of this study was to investigate the plasma soluble tumour necrosis factor related apoptosis-inducing ligand (sTrAıL) level in rheumatoid arthritis (rA) and to evaluate the relationship between sTrAıL and disease activity. Material and Methods: 19 rA patients, and as a control group 31 primary Sjogren's syndrome (pSS) patients and 24 healthy subjects were included in the study. Disease activity of rA patients was calculated by the Disease Activity Score-28 (DAS-28). Plasma sTrAıL concentrations were measured by the enzyme linked immunosorbent assay (eLıSA).Results: Mean plasma sTrAıL concentration in rA patients (1751 ± 635 pg/ml) was higher than in disease control patients with pSS (1234 ± 625 pg/ml) and in healthy controls (1181 ± 304 pg/ml) (p=0.002). ın rA patients, there was no correlation between mean DAS-28 score and plasma sTrAıL levels. And also, there was no correlation between sTrAıL levels and laboratory parameters indicating disease activity such as the erythrocyte sedimentation rate (eSr) and C-reactive protein (CrP). Conclusion: Plasma sTrAıL levels were significantly higher in rA regardless of disease activity. These findings suggest that sTrAıL may have an important role in the pathogenesis of rheumatoid arthritis.

Özet

Amaç: Çalışmanın amacı romatoid artritte plazmada çözünmüş TnF ilişkili apoptoz tetikleyici ligand (sTrAıL) düzeyinin saptanması ve sTrAıL düzeyinin hastalık aktivitesi ile ilişkisinin araştırılmasıdır. Gereç ve Yöntemler: 19 romatoid artrit (rA) hastası ve kontrol grubu olarak belirlenen 31 primer Sjögren sendromu (pSS) hastası ile 24 sağlıklı kişi çalışmaya dahil edildi. rA hastalarının hastalık aktivitesi, hastalık aktivite skoru-28 (DAS-28) ile hesaplandı. Plazma sTrAıL düzeyi immunoenzimatik yöntem (eLıSA) ile ölçüldü. Bulgular: Ortalama sTrAıL düzeyi rA hastalarında (1751 ± 635 pg/ml), pSS hastaları (1234 ± 625 pg/ml) ve sağlıklı kontrol (1181 ± 304 pg/ml) grubundan daha yüksek olarak ölçüldü (p=0.002). rA hastalarında DAS-28 ve sTrAıL düzeyi arasında bir korelasyon saptanmadı. Ayrıca sTrAıL düzeyi ile hastalık aktivitesini gösteren eSr ve CrP arasında da korelasyon saptanmadı. Sonuç: rA'li hastaların sTrAıL düzeyleri hastalık aktivitesinden bağımsız olarak anlamlı düzeyde artmaktadır. Bu bulgular sTrAıL'in rA patogenezinde önemli bir rol alabileceğini göstermektedir.

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Cite This Article

YAZISIZ, V., TERZİOĞLU, E., ERBASAN, F., KAHRAMAN, M. (2022). The relationship Between Plasma sTrAıL Level and Disease Activity in rheumatoid Arthritis. Akdeniz Tıp Dergisi, Cilt: 3 - Sayı: 2, 95–100. https://ajindex.com/articles/434482

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