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Journals / Akdeniz Tıp Dergisi / 2019 / Cilt: 5 - Sayı: 1

IL-12, IFN-γ and sIL-2 Levels in Bronchoalveolar Lavage of Patients with Pulmonary Tuberculosis

Akciğer Tüberkülozlu Hastaların Bronkoalveolar Lavajında İL-12, İFN-γ ve sİL-2 Düzeyleri

Veysel YILMAZ
Murat ACAT
Pages
112–115
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: When the IL-12, IFN-γ and sIL-2 levels were compared in the patient and control groups, the IL-12 and IFN-γ levels were found to show a significant difference (p: 0.02 and p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to compare cytokine levels (IL-12, IFN-γ and IL-2), thought to reflect local immunologic response, in sputum smear positive and negative patients by measuring them in bronchoalveolar lavage fluid in this study.
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Key Findings & Data:A total of 24 tuberculosis patients who were examined and treated at Yedikule Chest Diseases and Chest Surgery Training and Research Hospital between October 1998 and February 1999 were included.
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Conclusion & Impact:Results: When the IL-12, IFN-γ and sIL-2 levels were compared in the patient and control groups, the IL-12 and IFN-γ levels were found to show a significant difference (p: 0.02 and p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to compare cytokine levels (IL-12, IFN-γ and IL-2), thought to reflect local immunologic response, in sputum smear positive and negative patients by measuring them in bronchoalveolar lavage fluid in this study. Material and Methods: The study had a retrospective design. A total of 24 tuberculosis patients who were examined and treated at Yedikule Chest Diseases and Chest Surgery Training and Research Hospital between October 1998 and February 1999 were included. Patients without pulmonary malignancy and tuberculosis who had undergone bronchoscopy for other reasons were included as the control group. Results: When the IL-12, IFN-γ and sIL-2 levels were compared in the patient and control groups, the IL-12 and IFN-γ levels were found to show a significant difference (p: 0.02 and p

Özet

Amaç: Çalışmamızda lokal immün cevabı yansıttığı düşünülen sitokin seviyelerini (İL-12, İFN-γ vesİL-2) bronkoalveolar lavaj sıvısında ölçerek balgamda yayma negatif saptanan hastalar ile balgamyayması pozitif olan hastaları karşılaştırmayı amaçladık.Gereç ve Yöntemler: Çalışma retrospektif olarak dizayn edildi. Çalışmaya Ekim 1998-Şubat 1999arasında Yedikule Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi’nde tetkik vetedavi edilen 24 tüberküloz hastası alındı. Kontrol grubu olarak diğer nedenlerle bronkoskopi yapılmışolan akciğer malignitesi veya tüberkülozu olmayan 15 hasta alındı.Bulgular: Hasta ve kontrol grupları İL-12, İFN-γ ve sİL-2 düzeyleri açısından karşılaştırıldığındaİL-12 ve İFN-γ düzeylerinin anlamlı şekilde farklı olduğu tespit edildi (sırasıyla p: 0,02 ve p

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Cite This Article

YILMAZ, V., ACAT, M. (2022). IL-12, IFN-γ and sIL-2 Levels in Bronchoalveolar Lavage of Patients with Pulmonary Tuberculosis. Akdeniz Tıp Dergisi, Cilt: 5 - Sayı: 1, 112–115. https://ajindex.com/articles/434418

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