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Journals / Akdeniz Tıp Dergisi / 2019 / Cilt: 5 - Sayı: 3

The Protective Effects of Pentoxifylline on Contrast Induced Nephropathy in Rats

Ratlarda Pentoksifilinin Kontrast Nefropatisi Üzerine Koruyucu Etkileri

Süleyman ŞAHİN
Turgay ARINSOY
Şükrü SİNDEL
Yasemin ERTEN
Kadriye ALTOK
Ülver BOZTEPE DERİCİ
Fatih KARATAŞ
Suna OMEROGLU
Hatice PASAOGLU
Pages
429–438
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Basal and post-CIN kidney function parameters, inflammatory parameters, serum and renal tissue oxidative stress markers serum levels of advanced oxidation protein product and malondialdehyde , and histopathological lesions were assessed.Results: The increase in serum creatinine and blood urea nitrogen levels was significantly higher only in the CM group P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Pentoxifylline PTX , which has antioxidant and immunomodulatory effects, has been shown to attenuate renal ischemia-reperfusion injury.
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Key Findings & Data:We aimed to investigate whether PTX might have a preventive role against the development of contrast induced nephropathy CIN .Material and Methods: A total of 24 Wistar-albino female rats were randomly divided into four groups n=6 each as follows; control C , contrast material CM , PTX, and PTX+CM.
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Conclusion & Impact:Basal and post-CIN kidney function parameters, inflammatory parameters, serum and renal tissue oxidative stress markers serum levels of advanced oxidation protein product and malondialdehyde , and histopathological lesions were assessed.Results: The increase in serum creatinine and blood urea nitrogen levels was significantly higher only in the CM group P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kontrast nefropatisi · Pentoksifilin · Böbrek

Abstract

Objective: Pentoxifylline PTX , which has antioxidant and immunomodulatory effects, has been shown to attenuate renal ischemia-reperfusion injury. We aimed to investigate whether PTX might have a preventive role against the development of contrast induced nephropathy CIN .Material and Methods: A total of 24 Wistar-albino female rats were randomly divided into four groups n=6 each as follows; control C , contrast material CM , PTX, and PTX+CM. Except the control and CM groups, the groups were given PTX once daily orally for 5 days. CIN was induced by administration of intravenous high-osmole contrast material-diatrizoate 6 mL/kg after 48 hour of dehydration. Basal and post-CIN kidney function parameters, inflammatory parameters, serum and renal tissue oxidative stress markers serum levels of advanced oxidation protein product and malondialdehyde , and histopathological lesions were assessed.Results: The increase in serum creatinine and blood urea nitrogen levels was significantly higher only in the CM group P

Özet

Amaç: Antioksidan ve immüno-modülatör etkileri olan pentoksifilinin PTX , renal iskemi-reperfüzyon hasarını azalttığı gösterilmiştir. PTX’in kontrast kaynaklı nefropatinin CIN gelişmesine karşı koruyucu bir rolü olup olmadığını araştırdık.Gereç ve Yöntemler: Toplam 24 tane wistar-albino dişi sıçan rastgele-altışarlı kontrol C , kontrast madde CM , PTX ve PTX + CM şeklinde dört gruba ayrıldı. Kontrol ve CM grupları haricindekilere 5 gün boyunca günde bir kez PTX verildi. CIN, 48 saat dehidrasyondan sonra intravenöz yüksek ozmolar kontrast madde olan -diatrizoatla 6 mL/kg indüklendi. Bazal ve post-CIN böbrek fonksiyon parametreleri, inflamatuar parametreler, serum ve renal doku oksidatif stres belirteçleri ileri oksidasyon protein ürünü ve malondialdehid serum seviyeleri ve histopatolojik lezyonlar değerlendirildi.Bulgular: Serum kreatinin ve kan üre nitrojen düzeylerindeki artış ve kreatin klerensinde azalma sadece CM grubunda anlamlıydı P

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Cite This Article

ŞAHİN, S., ARINSOY, T., SİNDEL, Ş., ERTEN, Y., ALTOK, K., DERİCİ, Ü. B., KARATAŞ, F., OMEROGLU, S., PASAOGLU, H. (2022). The Protective Effects of Pentoxifylline on Contrast Induced Nephropathy in Rats. Akdeniz Tıp Dergisi, Cilt: 5 - Sayı: 3, 429–438. https://ajindex.com/articles/434411

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