Journals / Akdeniz Tıp Dergisi / 2020 / Cilt: 6 - Sayı: 3

Relationship between Serum Levels of BNP and Left Ventricular Mechanics with Severity of Mitral Regurgitation in Asymptomatic Patients with Organic Mitral Regurgitation and Preserved Left Ventricular Function

Organik Mitral Yetmezlikli ve Sol Ventrikül Fonksiyonu Korunmuş Asemptomatik Hastalarda BNP Serum Düzeyleri ile Sol Ventrikül Mekaniği ve Mitral Yetersizliği Ciddiyeti Arasındaki İlişki

Pages
364–372
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients were divided into two groups according to their BNP value [≥140 pg/ml group 1 and

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In moderate and severe mitral regurgitation MSMR , left ventricular systolic dysfunction develops in time.
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Key Findings & Data:We aimed to investigate the effect of mitral regurgitation on left ventricular mechanics as assessed with 2D strain echocardiography.
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Conclusion & Impact:Patients were divided into two groups according to their BNP value [≥140 pg/ml group 1 and
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Brain natriüretik peptit · Ekokardiyografi · Global longitudinal strain

Abstract

Objective: In moderate and severe mitral regurgitation MSMR , left ventricular systolic dysfunction develops in time. We aimed to investigate the effect of mitral regurgitation on left ventricular mechanics as assessed with 2D strain echocardiography. We also sought to explore the correlation between BNP and severity of MR and also between BNP and LV mechanics.Material and Methods: Twenty four asymptomatic patients with organic MSMR were included. Left ventricular global longitudinal strain LV-GLS , global circumferential strain and global radial strain were calculated and serum BNP was measured. Patients were divided into two groups according to their BNP value [≥140 pg/ml group 1 and

Özet

Amaç: Orta ve ciddi mitral yetersizliğinde, sol ventrikül sistolik disfonksiyonu zamanla gelişir. Biz bu çalışmada, mitral yetersizliğinin, sol ventrikül mekanik fonksiyonlarına olan etkisini 2D strain ekokardiyografi ile araştırmayı amaçladık. Ayrıca BNP seviyesi ile LV mekaniği ve MY ciddiyeti arasındaki ilişkiyi araştırdık.Gereç ve Yöntemler: Organik orta ciddi mitral yetmezliği olan yirmi dört asemptomatik hasta çalışmaya dahil edildi. Sol ventrikül global longitudinal strain LV-GLS , global sirkumferensiyal ve global radyal strain hesaplandı ve serum BNP düzeyi ölçüldü. BNP değerlerine göre [≥140 pg /ml grup 1 ve

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Cite This Article

DEMİR, F. A., PAPACHRISTIDIS, A., ALTEKİN, R. E., DEMİR, İ. (2022). Relationship between Serum Levels of BNP and Left Ventricular Mechanics with Severity of Mitral Regurgitation in Asymptomatic Patients with Organic Mitral Regurgitation and Preserved Left Ventricular Function. Akdeniz Tıp Dergisi, Cilt: 6 - Sayı: 3, 364–372. https://ajindex.com/articles/434284

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References (9)

  1. Ling LH, Enriquez-Sarano M, Seward JB, Tajik AJ, Schaff HV, Bailey KR, Frye RL. Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med 1996; 335:1417-23.
  2. Delahaye JP, Gare JP, Viguier E, Delahaye F, De Gevigney G, Milon H. Natural history of severe mitral regurgitation. Eur Heart J 1991; 12 suppl B:5-9.
  3. Baumgartner H, Falk V, Bax J, Bonis M, Hamm C, Holm P, Lung B, Lancellotti P, Lansac E, Rosenhek D, Sjögren J, Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano J. ESC Scientific Document Group. Guidelines for the management of valvular heart disease: The task force for the management of valvular heart disease of the european society of cardiology and the european association for cardio-thoracic surgery. Eur Heart J 2017; 38:2739-91.
  4. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Fleisher LA, Jneid H,Mack MJ, McLeod CJ, O’Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A. 2017 AHA/ACC focused update of the 2014 AHA/ ACC guideline for the management of patients with valvular heart disease. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Circulation 2017; 135:e1159-e95. Ahmed MI, Gladden JD, Litovsky SH, Lloyd SG, Gupta H, Inusah S, Denney T Jr, Powell P, McGiffin DC, Dell’Italia LJ. Increased oxidative stress and cardiomyocytemyofibrillar degeneration in patients with chronic isolated mitral regurgitation and ejection fraction >60%. J Am Coll Cardiol 2010; 55:671-9.
  5. Konstam MA, Abboud FM. Ejection fraction: Misunderstood and overrated (changing the paradigm in categorizing heart failure). Circulation 2017; 135:717-9.
  6. Topilsky Y, Suri R, Schaff H V, Enriquez-Sarano M. When to intervene for asymptomatic mitral valve regurgitation. Semin Thorac Cardiovasc Surg 2010; 22:216-24.
  7. Marwick TH, Leano RL, Brown J, Sun JP, Hoffmann R, Lysyansky P, Becker M, Thomas JD. Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: Definition of normal range. JACC Cardiovasc Imaging 2009; 2:80-4.
  8. Chan J, Hanekom L, Wong C, Leano R, Cho GY, Marwick TH. Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function. J Am Coll Cardiol 2006; 48:2026-33.
  9. Lancellotti P, Cosyns B, Zacharakis D, Attena E, Van Camp G, Gach O, Radermecker M, Piérard LA. Importance of left ventricular longitudinal function and functional reserve in patients with degenerative mit