Journals / Akdeniz Tıp Dergisi / 2022 / Cilt: 8 - Sayı: 3

Fetal Left Acheiria in Levetiracetam Use During Pregnancy: A Case Report

Levetirasetam Kullanan Gebede Fetal Sol El Yokluğu: Olgu Sunumu

Pages
360–363
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report a case of LEV use during pregnancy and absence of the left hand (acheiria) in the fetus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Epilepsy is a chronic disease that can also occur during pregnancy.
📊
Key Findings & Data:Congenital malformation (CM) rates increase especially with first-generation antiepi- leptic use.
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Conclusion & Impact:We report a case of LEV use during pregnancy and absence of the left hand (acheiria) in the fetus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Epilepsy is a chronic disease that can also occur during pregnancy. There are serious maternal and fetal risks of having an epileptic seizure, so it is necessary to continue treatment during pregnancy. Congenital malformation (CM) rates increase especially with first-generation antiepi- leptic use. Levetiracetam (LEV) is a second generation antiepileptic with relatively few terato- genic side effects. Although there are publications about CM in pregnant women using LEV, no malformation specific to this drug has been reported. We report a case of LEV use during pregnancy and absence of the left hand (acheiria) in the fetus.

Özet

Epilepsi gebelik sırasında da görülebilen, kronik bir hastalıktır. Epileptik nöbet geçirmenin ciddi maternal ve fetal riskleri vardır, bu nedenle gebelikte tedaviye devam etmek gerekir. Konjenital malformasyon (KM) oranları özellikle birinci kuşak antiepileptik kullanımı ile artmaktadır. Levetirasetam (LEV) ise ikinci kuşak antiepileptik olup, teratojenik yan etkileri daha azdır. LEV kullanan gebede KM ile ilgili yayınlar olmasına rağmen, bu ilaca özgü herhangi bir malformasyon bildirilmemiştir. Biz, gebeliği boyunca LEV kullanan ve fetüste sol el yokluğu (acheiria) izlenen bir vakayı bildirmekteyiz

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Cite This Article

KANDEMİR, H., SANHAL, C. Y., SAKINCI, M. (2022). Fetal Left Acheiria in Levetiracetam Use During Pregnancy: A Case Report. Akdeniz Tıp Dergisi, Cilt: 8 - Sayı: 3, 360–363. https://ajindex.com/articles/434193

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References (12)

  1. MacDonald SC, Bateman BT, McElrath TF, Hernández-Díaz S: Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States. JAMA neurology 2015; 72(9):981-8
  2. Mawhinney E, Craig J, Morrow J, Russell A, Smithson WH, Parsons L, Morrison PJ, Liggan B, Irwin B, Delanty N, Hunt, S.J.: Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 2013; 80(4):400-5
  3. Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F: Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. The Lancet Neurology 2018; 17(6):530-8
  4. Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, Morrison PJ, Liggan B, Irwin B, Delanty N, Hunt SJ, Craig, J, Morrow, J: Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. Journal of neurology, neurosurgery, and psychiatry 2014; 85(9):1029-34
  5. Stoll C, Alembik Y, Dott B, Roth MP: Evaluation of prenatal diagnosis of limb reduction defects by a registry of congenital anomalies. Prenatal diagnosis 1994; 14(9):781-6
  6. Holmes LB, Harvey EA, Coull BA, Huntington KB, Khoshbin S, Hayes AM, Ryan LM: The teratogenicity of anticonvulsant drugs. The New England journal of medicine 2001; 344(15):1132-8
  7. Battino D, Tomson T, Bonizzoni E, Craig J, Lindhout D, Sabers A, Perucca E, Vajda F: Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia 2013; 54(9):1621-7
  8. Mawer G, Briggs M, Baker GA, Bromley R, Coyle H, Eatock J, Kerr L, Kini U, Kuzmyshcheva L, Lucas SB, Wyatt, L, Clayton-Smith, J: Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study. Seizure 2010; 19(2):112-9
  9. Vajda FJE, Graham JE, Hitchcock AA, Lander CM, O'Brien TJ, Eadie MJ: Antiepileptic drugs and foetal malformation: analysis of 20 years of data in a pregnancy register. Seizure 2019; 65:6-11
  10. Blotière PO, Raguideau F, Weill A, Elefant E, Perthus I, Goulet V, Rouget F, Zureik M, Coste J, Dray-Spira R: Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs. Neurology 2019; 93(2):e167-e80
  11. Meador KJ, Loring DW: Developmental effects of antiepileptic drugs and the need for improved regulations. Neurology 2016; 86(3):297-306
  12. Chaudhry