Journals / Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2019 / Cilt: 19 - Sayı: 3

Synthesis and Antimicrobial Activity Studies of Thiazole Based Schiff Base and Their Metal Complexes

Tiyazol Tabanlı Schiff Bazı ve Metal Komplekslerinin Sentezi ve Antimikrobiyal Aktivite Çalışmaları

Pages
580–585
Publication Date
2022-10-12
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Ni(II) ve Zn(II) complexes were found to be weak active against Staphylococcus Aureus.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Schiff bases are increasingly important in analytical chemistry as well as in the production of dyes, preparation of certain drugs, electronics industry, plastics industry and various branches such as liquid crystal technology.
📊
Key Findings & Data:Structures of the synthesised compounds were clarified with elemental analysis, IR, 1H NMR, 13 C NMR spectral techniques.
💡
Conclusion & Impact:Ni(II) ve Zn(II) complexes were found to be weak active against Staphylococcus Aureus.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Schiff bases are increasingly important in analytical chemistry as well as in the production of dyes, preparation of certain drugs, electronics industry, plastics industry and various branches such as liquid crystal technology. In this study, thiazole Schiff base and its Cu(II), Ni(II) ve Zn(II) complexes were synthesised. Structures of the synthesised compounds were clarified with elemental analysis, IR, 1H NMR, 13 C NMR spectral techniques. Antimicrobial activities of the compounds have been tested against yeasts and bacterias. Ni(II) ve Zn(II) complexes were found to be weak active against Staphylococcus Aureus.

Özet

Schiff bazları analitik kimyada olduğu kadar boyar maddelerin üretiminde, bazı ilaçlarınhazırlanmasında, elektronik endüstrisinde, plastik sanayiinde ve sıvı kristal teknolojisi gibi çeşitlidallarda gittikçe artan öneme sahip maddelerdir. Bu çalışmada tiyazol tabanlı Schiff bazı ile nikel, bakırve çinko metal kompleksleri sentezlenmiştir. Sentezlenen bileşiklerin yapıları element analizi IR, 1HNMR, 13C NMR spektroskopik yöntemleriyle aydınlatılmıştır. Bileşiklerin bakteri ve mantarlara karşıantimikrobiyal aktiviteleri araştırılmıştır. Ni(II) ve Zn(II) komplekslerinin Staphylococcus aureus a karşızayıf aktivite gösterdiği bulunmuştur.

🔖

Cite This Article

ÇUKUROVALI, A., YILMAZ, İ. (2022). Synthesis and Antimicrobial Activity Studies of Thiazole Based Schiff Base and Their Metal Complexes. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 19 - Sayı: 3, 580–585. https://ajindex.com/articles/429906

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Agrawal, Y.K., 1979. Hydroxamic Acids and Their Metal Complexes. Russ. Chem. Res., 48 (10), 948. Bagihalli, G.B., Avaji, P.G. Patil, S. A., Badami, P.S. 2008. Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases, European Journal of Medicinal Chemistry 43, 2639-2649.
  2. Bekaroğlu, Ö., 1972.
  3. Koordinasyon Kimyası, İ.Ü. Kimya Fak., İstanbul.
  4. Beyer, H., 1963.
  5. Organic Chemistry, Verlag Harry Deutsch, Frankfurt / Main und Zurich, 609-610.
  6. Burger, K., 1973.
  7. Organic Reagents in Metal Analysis, Pergamon Press,
  8. New York. Cotton F.A. and Wilkinson, G. 1988.
  9. Advanced Inorganic Chemistry, The Elements of the First Transition Series, A Wiley-Interscience Publication, Wiley, New York. Cukurovali, A. and Yilmaz, I. 2000. Synthesis and Characterization of a New Cyclobutane Substituted Schiff Base Ligand and Its Cd(II), Co(II), Ni(II) and Zn(II) Complexes", Polish Journal of Chemistry, 74(1), 147-151
  10. Cukurovali, A. and Yilmaz, I. 2003. Salicylaldehyde Thiazolyl Hydrazones as Ligands", Heteroatom Chemistry, 14(7), 617-621.
  11. Dincer, M., Ozdemir, N., Cukurovali, A. and Yilmaz, I. 2005.
  12. Benzoin thiosemicarbazone, Acta Crystallographica E, 61(4), o880-o883. Dhar, D.B., and Taploo, C.C., 1982. Schiff bases and their applications. J. Scient. Ind. Res., 41 (8), 501. El-Tabl, A.S, Fathey A., El-Saied, W. P., Al-Hakimi, A.N. 2008. Synthesis, spectroscopic characterization and biological activity of the metal complexes of the Schiff base derived from phenylamino acetohydrazide and dibenzoylmethane, Spectrochimica Acta Part A 71, 90–99.
  13. Frust, A., 1963. Chemistry of Chelation of Cancer, p.105, CC Thomas, Llinois. Masoud, M.S., and Refaat, L.S., 1982. Synthesis and characterization of some nickel(II) Schiff-bases complexes. Trans. Met. Chem., 7, 315. Meffin, P.J., Williams, R.L., Blaschke, R.F., and Rowland, M., 1977.
  14. Pharmaceutical salts, J. Pharm. Sci., 66, 135. Metzler, D.E., and Snell, E., 1952. Some Transamination Reactions Involving Vitamin B61. J. Am. Chem. Soc., 74, 979. Murthy, A.S.N., and Reddy, A.R., 1981. Electronic absorption spectroscopic studies of enolimineketoamine equilibria in Schiff-bases Proc. Indian Acad. Sci.(Chem. Sci.), 90, 519. Pesavento, M., and Soldi, T., 1983. Spectrophotometric study and analytical applications of the complexes of copper(II) and zinc(II) with some sulphonated azo dyes. Analyst, 108, 1128-1134.
  15. Sawhney, S.N., Arora, S.K., and Sin