Association between inflammatory markers and primary hyperparathyroidism

Objective & Hypothesis:Aim: Primary hyperparathyroidism (PHP) is associated with systemic inflam-mation.The effect of parathyroidectomy (PTX) on inflammatory markers is contro-versial.The aim of our study was to investigate changes in inflammatory markers includingC-reactive protein (hs-CRP), platelet-to-lymphocyte ratio (PLR), and red celldistribution width (RDW) before and after PTX.Patients and Methods: PHP patients (n=55) and age and sex matched healthycontrols (n=50) were included in the study.

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Key Findings & Data:The clinical and laboratory results of thePHP and control groups were compared before PTX and 6-months after PTX.Results: At baseline, serum hs-CRP (4.01±3.44 vs. 2.48±1.73 mg/L), PLR(127.21±25.77 vs. 103.63±32.52), RDW (15.50±2.53 % vs. 13.49±0.70 %) valueswere higher in the PHP group than in the control group (p 0.05).

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Conclusion & Impact:İnflammation occurs in PHP patients, and also shows a partial recovery from inflammationdespite successful surgery

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: Primary hyperparathyroidism (PHP) is associated with systemic inflam-mation.The effect of parathyroidectomy (PTX) on inflammatory markers is contro-versial.The aim of our study was to investigate changes in inflammatory markers includingC-reactive protein (hs-CRP), platelet-to-lymphocyte ratio (PLR), and red celldistribution width (RDW) before and after PTX.Patients and Methods: PHP patients (n=55) and age and sex matched healthycontrols (n=50) were included in the study. The clinical and laboratory results of thePHP and control groups were compared before PTX and 6-months after PTX.Results: At baseline, serum hs-CRP (4.01±3.44 vs. 2.48±1.73 mg/L), PLR(127.21±25.77 vs. 103.63±32.52), RDW (15.50±2.53 % vs. 13.49±0.70 %) valueswere higher in the PHP group than in the control group (p 0.05). Post-PTX hs-CRP, PLR, and RDW values were higher in the PHP groupthan in the control group (p<0.05). PTH value was positively correlated with pre-PTXhs-CRP (r2=0.377, p=0.001), PLR (r2=0.234, p=0.023), RDW (r2=0.296, p=0.004).Conclusion: Before PTX, inflammatory markers were higher in PHP patients compared with healthy controls. After PTX, the inflammatory markers did not significantlydecrease; however these postoperative markers were higher than controls. İnflammation occurs in PHP patients, and also shows a partial recovery from inflammationdespite successful surgery

Özet

Amaç: Primer hiperparatiroidizm (PHP) sistemik inflamasyonla ilişkilidir. Paratiroidektominin (PTX) inflamatuar b elirteçler ü zerindeki e tkisi tartışmalıdır. Çalışmamızın amacı, PTX öncesi ve sonrası C-reaktif protein (hs-CRP), trombosit / lenfosit oranı (TLO) ve kırmızı hücre dağılım genişliğini (RDW) içeren inflamatuar belirteçlerdeki değişiklikleri araştırmaktı. Hastalar ve Yöntem: Çalışmaya PHP hastaları (n=55) ve yaş ve cinsiyet eşleştirilmiş sağlıklı kontroller (n=50) dahil edildi. PHP ve kontrol gruplarının klinik ve laboratuar sonuçları PTX'den önce ve PTX’den 6 ay sonra karşılaştırıldı. Bulgular: Başlangıçta, serum hs-CRP (4,01±3,44’e karşın 2,48±1,73 mg/L), TLO (127,21±25,77’e karşın 103,63±32,52), RDW (15,50±2,53’e karşın 13,49±0,70 %) değerleri PHP grubunda, kontrol grubundan daha yüksekti (p 0,05). PTX sonrası hs-CRP, TLO ve RDW değerleri PHP grubunda, kontrol grubundan daha yüksekti (p<0,05). PTH değeri, PTX öncesi hs-CRP (r2=0,377, p=0,001), TLO (r2=0,234, p=0,023), RDW (r2=0,296, p=0,004) ile pozitif olarak korele idi. Sonuç: PTX’den önce, PHP hastalarında inflamatuar belirteçler sağlıklı kontrollere kıyasla daha yüksekti. PTX'ten sonra, inflamatuar belirteçler istatiksel anlamlı azalmadı; ancak bu ameliyat sonrası belirteçler kontrollerden daha yüksekti. İnflamasyon PHP hastalarında görülür ve aynı zamanda başarılı bir ameliyat olmasına rağmen inflamasyondan kısmen iyileşme gösterir.

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Cite This Article

BEYSEL, S., ÖZBEK, M., ÇAKAL, E., KIZILGÜL, M., ÇALIŞKAN, M., ÇİLEKAR, M. (2022). Association between inflammatory markers and primary hyperparathyroidism. Acta Medica Alanya, Cilt: 3 - Sayı: 3, 241–247. https://ajindex.com/articles/425891

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