A higher BMD gain (g/cm2) was seen in the lumbar spine (10.83% vs. 4.65%, P=0.016) and femoral neck (12.61% vs.4.37%, P=0.005) in symptomatic PHPT compared to the asymptomatic PHPT group.Conclusion: Parathyroidectomy provided more BMD gain in the lumbar spine and femoral neck in patients with symptomatic PHPTwhen compared to patients with asymptomatic PHPT 1 year after parathyroidectomy.
📌 3 Key Takeaways
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Objective & Hypothesis:Background/aim: This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomyin patients with primary hyperparathyroidism (PHPT).Materials and methods: The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n = 28)and asymptomatic PHPT (n = 63) were investigated before and 1 year after parathyroidectomy.Results: Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2% vs. 4.6%, P = 0.032) when compared to theprevalence in patients with asymptomatic PHPT.
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Key Findings & Data:The prevalence of osteoporosis in the lumbar spine (63.0% vs. 37.5%, P = 0.026) andfemoral neck (40.7% vs. 20.6%, P = 0.048) was higher in symptomatic PHPT when compared to the prevalence in asymptomatic PHPT.After parathyroidectomy, the decreases in the prevalence of osteoporosis in the lumbar spine (25.8% vs. 9.4%, P = 0.014), femoral neck(22.1% vs. 8.2%, P =0.009), and total hip (22.4% vs. 5.3%, P = 0.007) were higher in symptomatic PHPT compared to the asymptomaticPHPT group.
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Conclusion & Impact:A higher BMD gain (g/cm2) was seen in the lumbar spine (10.83% vs. 4.65%, P=0.016) and femoral neck (12.61% vs.4.37%, P=0.005) in symptomatic PHPT compared to the asymptomatic PHPT group.Conclusion: Parathyroidectomy provided more BMD gain in the lumbar spine and femoral neck in patients with symptomatic PHPTwhen compared to patients with asymptomatic PHPT 1 year after parathyroidectomy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Background/aim: This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomyin patients with primary hyperparathyroidism (PHPT).Materials and methods: The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n = 28)and asymptomatic PHPT (n = 63) were investigated before and 1 year after parathyroidectomy.Results: Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2% vs. 4.6%, P = 0.032) when compared to theprevalence in patients with asymptomatic PHPT. The prevalence of osteoporosis in the lumbar spine (63.0% vs. 37.5%, P = 0.026) andfemoral neck (40.7% vs. 20.6%, P = 0.048) was higher in symptomatic PHPT when compared to the prevalence in asymptomatic PHPT.After parathyroidectomy, the decreases in the prevalence of osteoporosis in the lumbar spine (25.8% vs. 9.4%, P = 0.014), femoral neck(22.1% vs. 8.2%, P =0.009), and total hip (22.4% vs. 5.3%, P = 0.007) were higher in symptomatic PHPT compared to the asymptomaticPHPT group. A higher BMD gain (g/cm2) was seen in the lumbar spine (10.83% vs. 4.65%, P=0.016) and femoral neck (12.61% vs.4.37%, P=0.005) in symptomatic PHPT compared to the asymptomatic PHPT group.Conclusion: Parathyroidectomy provided more BMD gain in the lumbar spine and femoral neck in patients with symptomatic PHPTwhen compared to patients with asymptomatic PHPT 1 year after parathyroidectomy.
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Cite This Article
ÖZBEK, M., KIZILGÜL, M., ÇALIŞKAN, M., ÇAKAL, E., BEYSEL, S. (2022). The effect of parathyroidectomy on bone mineral density in primary hyperparathyroidism. Turkish Journal of Medical Sciences, Cilt: 49 - Sayı: 6, 1674–1680. https://ajindex.com/articles/609889
Cordellat IM. Hyperparathyroidism: primary or secondary disease? Reumatologia Clinica 2012
8 (5): 287-91. doi: 10.1016/j.reuma.2011.06.001 2. Silverberg SJ, Clarke BL, Peacock M, Bandeira F, Boutroy S et al. Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. Journal of Clinical Endocrinology and Metabolism 2014
99 (10): 3580-3894. doi: 10.1210/jc.2014-1415 3. Bandeira F, Cusano NE, Silva BC, Cassibba S, Almeida CB et al. Bone disease in primary hyperparathyroidism. Arquvios Brasileiros de Endocrinologia and Metabologia 2014
58 (5): 553-361. doi: 10.1590/0004-2730000003381 4. Vestergaard P, Mosekilde L. Fractures in patients with primary hyperparathyroidism: nationwide follow-up study of 1201 patients. World Journal of Surgery 2003
doi: 10.1007/s00268-002-6589-9 5. Yu N, Donnan PT, Flynn RWV, Murphy MJ, Smith D et al. Increased mortality and morbidity in mild primary hyperparathyroid patients. The Parathyroid Epidemiology and Audit Research Study (PEARS). Clinical Endocrinology 2010
doi: 10.1111/j.1365-2265.2009.03766.x 6. Roschger P, Dempster DW, Zhou H, Paschalis EP, Silverberg SJ et al. New observations on bone quality in mild primary hyperparathyroidism as determined by quantitative backscattered electron imaging. Journal of Bone and Mineral Research 2007
doi: 10.1359/jbmr.070120 7. Siilin H, Lundgren E, Mallmin H, Mellström D, Ohlsson C et al. Prevalence of primary hyperparathyroidism and impact on bone mineral density in elderly men: MrOs Sweden. World Journal of Surgery 2011
doi: 10.1007/s00268- 011-1062-2 8. Vignali E, Viccica G, Diacinti D, Cetani F, Cianferotti L et al. Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism 2009
doi: 10.1210/jc.2008-2006 9. Bandeira F, Griz L, Chaves N, Carvalho NC, Borges LM et al. Diagnosis and management of primary hyperparathyroidism--a scientific statement from the Department of Bone Metabolism, the Brazilian Society for Endocrinology and Metabolism. Arquivos Brasileiros de Endocrinologia and Metabologia 2013
doi: 10.1590/s0004-27302013000600002 10. Tamura Y, Araki A, Chiba Y, Mori S, Hosoi T et al. Remarkable increase in lumbar spine bone mineral density and amelioration in biochemical markers of bone turnover after parathyroidectomy in elderly patients wit