Journals / Molecular Imaging and Radionuclide Therapy / 2022 / Cilt: 31 - Sayı: 1

Investigation of Added Value of Imaging Performed in a Prone Position to Standard 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer

Meme Kanserli Hastalarda Evreleme için Yapılan Standart 18 F-Florodeoksiglukoz Pozitron Emisyon Tomografi/Bilgisayarlı Tomografi Görüntülemesine Yüzüstü Pozisyonda Yapılan Görüntülemenin Katkısının Araştırılması

Pages
23–32
Publication Date
2022-09-03
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement.

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Objective & Hypothesis:Objectives: To investigate whether additional imaging in a prone position has any value to the supine whole-body18 fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images by comparing the visual and quantitative data about a local disease in the breast and axilla for the initial staging of breast cancer (BC).
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Key Findings & Data:Methods: In this study, a total of 91 female patients with the BC were studied.
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Conclusion & Impact:However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To investigate whether additional imaging in a prone position has any value to the supine whole-body18 fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images by comparing the visual and quantitative data about a local disease in the breast and axilla for the initial staging of breast cancer (BC). Methods: In this study, a total of 91 female patients with the BC were studied. Both the supine and prone images were examined based on the axial diameter, number and location of the primary tumor, local invasion signs of the tumor, the number of axillary lymph nodes with a suspected metastasis, metabolic parameters of the primary tumor and axillary lymph nodes, and registration artifacts of the PET and CT images were evaluated individually. These findings were compared with the histopathological data obtained after a surgery. Results: In the evaluation of a supine and prone imaging, tumor diameter and metabolic tumor volume (MTV) values of the breast lesions were greater in the supine position than in the prone position. However, there was no significant difference found between the other metabolic parameters of a primary tumor and axilla in both positions. In the supine and prone images, accuracy for skin involvement was 84% and 91.3%, respectively. Conclusion: In our study, we observed that, obtaining additional images in the prone position does not significantly benefit the evaluation of a local disease. The average values of the primary tumor diameter and MTV in the prone position appear to be smaller than the one in the supine position. However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement.

Özet

Amaç: Meme kanserinin ilk evrelendirmesi için yapılan görüntülemede, meme ve aksilladaki lokal hastalık hakkındaki görsel ve niceliksel verileri karşılaştırarak, pron pozisyonda bölgesel görüntülemenin, standart tüm vücut 18 flor-florodeoksiglukoz pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) görüntülerine ek katkısının olup olmadığını araştırmak. Yöntem: Doksan bir meme kanserli kadın hasta incelendi. Hem supin hem de pron görüntüler; aksiyal çap, primer tümörün sayısı ve yeri, tümörün lokal invazyon bulguları, metastaz şüpheli aksiller lenf nodu sayısı, primer tümör ve aksillar lenf nodlarının metabolik parametreleri ile, PET ve BT görüntülerinin füzyon artefaktları ayrı ayrı değerlendirildi. Bu bulgular ameliyat sonrası elde edilen histopatolojik verilerle karşılaştırıldı. Bulgular: Meme lezyonlarının tümör çapı ve metabolik tümör hacmi (MTV) değerleri supin pozisyonda, pron pozisyona göre daha yüksekti. Bununla birlikte, her iki pozisyonda alınan görüntülerde primer tümör ve aksillanın diğer metabolik parametreleri arasında önemli bir fark yoktu. Supin ve pron görüntülerde deri tutulumunun doğruluğu sırasıyla %84 ve %91,3 idi. Sonuç: Çalışmamızda, pron pozisyonda ek görüntü almanın, lokal hastalık değerlendirmesine anlamlı fayda sağlamadığını gözlemledik. Pron pozisyonda primer tümör çapı ve MTV’nin ortalama değerleri, sırtüstü pozisyondakinden daha küçük bulundu. Bununla birlikte, yeni tanı almış meme kanseri hastalarında, pron görüntüleme, seçilmiş hastalarda faydalı olabilir ve özellikle cilt tutulumu şüphesi olan hastalarda yanlış pozitif sonuçların önlenmesine katkıda bulunabilir.

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Cite This Article

Erdoğan, E. B., Aydın, M. (2022). Investigation of Added Value of Imaging Performed in a Prone Position to Standard 18 F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer. Molecular Imaging and Radionuclide Therapy, Cilt: 31 - Sayı: 1, 23–32. https://ajindex.com/articles/425684

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