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Journals / Molecular Imaging and Radionuclide Therapy / 2019 / Cilt: 28 - Sayı: 3

Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment

Soliter Pulmoner Nodül: Metabolik Aktivite Değerlendirmesinde Morfolojik Etkiler

Mehmet ERDOGAN
Sevim Süreyya SENGUL
Şehnaz EVRIMLER
Hüseyin AYDIN
Adnan KARAIBRAHIMOGLU
Pages
112–119
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was a significant difference between SPNs

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activityassessment.
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Key Findings & Data:To the best of our knowledge, this is the first study to compare the volumetric metabolic activity parameters according to themorphologic parameters of the nodules.Methods: In this retrospective study, 18F-FDG positron emission tomography and computed tomography scans performed between 2011 and2018 were evaluated by a nuclear and diagnostic radiologist.
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Conclusion & Impact:There was a significant difference between SPNs
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to evaluate the effects of morphological characteristics of the solitary pulmonary nodules (SPN) on metabolic activityassessment. To the best of our knowledge, this is the first study to compare the volumetric metabolic activity parameters according to themorphologic parameters of the nodules.Methods: In this retrospective study, 18F-FDG positron emission tomography and computed tomography scans performed between 2011 and2018 were evaluated by a nuclear and diagnostic radiologist. One hundred thirteen patients with SPNs with biopsy-proven diagnosis wereincluded. SPNs were classified as solid, partially solid (PS), and ground glass opacity (GGO).Results: SPN diameter, SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and density were significantly higher in the malignantgroup. SUVmax, MTV, TLG increased in direct proportion to the diameter. There was no a significant difference between GGO, PS, and solid nodulesin terms of SUVmax values. MTV and TLG values increased in parallel with the density of the nodules, but this increase was only significant in themalignant group. There was a significant difference between SPNs

Özet

Amaç: Soliter pulmoner nodüllerin (SPN) morfolojik özelliklerinin metabolik aktivite değerlendirmesi üzerindeki etkilerini değerlendirmeyi amaçladık. Bildiğimiz kadarıyla, volümetrik metabolik aktivite parametrelerini nodüllerin morfolojik parametrelerine göre karşılaştıran ilk çalışma budur. Yöntem: 2011 ve 2018 yılları arasında yapılan 18F-FDG pozitron emisyon tomografisi ve bilgisayarlı tomografi taramaları, bir nükleer tıp uzmanı ve radyoloji uzmanı tarafından retrospektif olarak değerlendirildi. Biyopsi ile kanıtlanmış tanısı olan 113 SPN hastası dahil edildi. SPN’ler solid, kısmi solid (PS) ve buzlu cam opasitesi (GGO) olarak sınıflandırıldı. Bulgular: SPN çapı, SUVmaks, metabolik tümör hacmi (MTV), toplam lezyon glikoliz (TLG) ve dansite malign grupta anlamlı olarak yüksek bulundu. SUVmaks, MTV ve TLG değerleri çap ile doğru orantılı olarak arttı. GGO, PS ve solid nodüller arasında SUVmaks değerleri arasında anlamlı bir fark yoktu. MTV, TLG değerleri nodüllerin yoğunluğu ile paralel olarak arttı; ancak sadece malign grupta anlamlı fark bulundu. 2 cm’den küçük grupta MTV için anlamlı fark varken SUVmaks için yoktu. ROC eğrisi ile belirlenen kesme değerinin SUVmaks için 4,39, MTV için 7,33 mL, TLG için 31,88 g olduğu bulundu. Solid ve subsolid nodüllerin SUVmaks için cut-off değeri birbirine yakındı, ancak MTV, TLG için cut-off değer solid nodüllerde daha yüksekti.

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Cite This Article

ERDOGAN, M., SENGUL, S. S., EVRIMLER, Ş., AYDIN, H., KARAIBRAHIMOGLU, A. (2022). Solitary Pulmonary Nodule: Morphological Effects on Metabolic Activity Assessment. Molecular Imaging and Radionuclide Therapy, Cilt: 28 - Sayı: 3, 112–119. https://ajindex.com/articles/653255

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