Journals / Turkish Neurosurgery / 2012 / Cilt: 22 - Sayı: 6

Kabul zamanındaki bilginin analizi temelinde anevrizmal subaraknoid kanamada tekrar kanama için risk faktörleri

Risk factors for rebleeding of aneurysmal subarachnoid hemorrhage based on the analysis of on-admission information

Pages
675–681
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

An earlier and more aggressive intervention may be applied to patients at high risk.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To provide a quick evaluation of rebleeding risk based on the on-admission patient information and to guide the management of patients for better outcome.
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Key Findings & Data:MaterIal and Methods: A retrospective review of 630 consecutive cases of subarachnoid hemorrhage (SAH) at a major medical center was conducted, of which 458 were included for analysis.
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Conclusion & Impact:An earlier and more aggressive intervention may be applied to patients at high risk.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: To provide a quick evaluation of rebleeding risk based on the on-admission patient information and to guide the management of patients for better outcome. MaterIal and Methods: A retrospective review of 630 consecutive cases of subarachnoid hemorrhage (SAH) at a major medical center was conducted, of which 458 were included for analysis. Sixty three cases of in-hospital pre-intervention rebleeding were identified. Chi-square or Mann-Whitney tests were used to screen for possible risk factors and values of the associated risk factors were assessed by logistic multivariate regression. Results: The identified risk factors were: short time interval between the first attack and hospitalization, gender (males were more susceptible), poor Hunt-Hess grade (III~V), high systolic pressure (>140 mmHg), intracerebral or intraventricular hematoma, high level of serum glucose (> 6.32 mmol/L) and high white blood cell count (> 12×10^9/L). Use of antifibrinolysis medication did not differ between groups. Subgroup analysis showed that posterior circulation aneurysms had a significantly higher rebleeding rate. Logistic regression analysis showed that intracerebral or intraventricular hematoma (p=0.010, OR=1.478) and blood glucose level above 6.32 mmol/L (p=0.011, OR=2.126) were independent risk factors. ConclusIon: We found a particularly high risk of rebleeding in patients with intracerebral or intraventricular hematoma or relatively high serum glucose level on admission. Posterior circulation aneurysms rebleed seemed more prominently manifested. An earlier and more aggressive intervention may be applied to patients at high risk.

Özet

AMAÇ: Kabul zamanındaki hasta bilgisi temelinde tekrar kanama riskinin hızlı bir değerlendirmesini sağlamak ve daha iyi bir sonuç için hasta takibine rehberlik yapmak. YÖNTEM ve GEREÇLER: Büyük bir tıbbi merkezde arka arkaya 630 subaraknoid kanama (SAK) vakasının retrospektif bir gözden geçirilmesi yapıldı ve bunların 458’i analize alındı. Hastanede girişim öncesi tekrar kanama 63 vakada tanımlandı. Olası risk faktörleri için taramak amacıyla ki kare veya Mann-Whitney testleri kullanıldı ve ilgili risk faktörlerinin değerleri lojistik multivaryant regresyonla değerlendirildi. BULGULAR: Tanımlanmış risk faktörleri şunlardır: birinci atak ile hastaneye yatma arasında kısa süre, cinsiyet (erkekler daha yatkındı), kötü Hunt-Hess sınıfı (III~V), yüksek sistolik basınç (>140 mmHg), intraserebral veya intraventriküler hematom, yüksek serum glukoz düzeyi (> 6,32 mmol/L) ve yüksek lökosit sayısı (> 12×10^9/L). Antifibrinoliz ilaçlarının kullanımı gruplar arasında farklılık göstermedi. Alt grup analizi posterior dolaşım anevrizmalarının daha yüksek bir tekrar kanama oranı olduğunu gösterdi. Lojistik regresyon analizi intraserebral veya intraventriküler hematomun (p=0,010, OR=1,478) ve 6,32 mmol/L üzerinde glukoz düzeyinin (p=0,011, OR=2,126) bağımsız risk faktörleri olduklarını gösterdi. SONUÇ: İntraserebral veya intraventriküler hematomu olan veya kabul zamanında serum glukoz düzeyi nispeten yüksek hastalarda özellikle yüksek bir tekrar kanama riski bulduk. Posterior dolaşım anevrizmalarının tekrar kanaması daha belirgin gibiydi. Yüksek riskli hastalarda daha erken ve daha agresif bir girişim kullanılabilir.

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Cite This Article

CONG, W., ZHONGXIN, Z., TIANGUI, L., ZHANG, Y., MIN, H., CHAO, Y. (2012). Kabul zamanındaki bilginin analizi temelinde anevrizmal subaraknoid kanamada tekrar kanama için risk faktörleri. Turkish Neurosurgery, Cilt: 22 - Sayı: 6, 675–681. https://ajindex.com/articles/417756

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