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Journals / Turkish Journal of Rheumatology(.)Archives of Rheumatology / 2012 / Cilt: 27 - Sayı: 4

Serum Antisiklik Sitrüline Peptid Antikorlarının Jüvenil İdiyopatik Artrit Açısından Klinik Değeri

The Clinical Value of Serum Anti-Cyclic Citrullinated Peptide Antibodies for Juvenile Idiopathic Arthritis

Xiaolan HUANG
Zheng XU
Fengqi WU
Xiaodai CUI
Xiaofeng LI
Xianzi CONG
Jianglin ZHANG
Pages
221–226
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Positive anti-CCP antibodies often indicate severe joint destruction

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to compare the levels of serum anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA) and adult rheumatoid arthritis (RA) and to discuss the clinical value of these antibodies in the diagnosis of JIA.
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Key Findings & Data:Patients and methods: This study was performed at the Capital Institute of Pediatrics in Beijing between February 2009 and December 2009.
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Conclusion & Impact:Positive anti-CCP antibodies often indicate severe joint destruction
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to compare the levels of serum anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA) and adult rheumatoid arthritis (RA) and to discuss the clinical value of these antibodies in the diagnosis of JIA. Patients and methods: This study was performed at the Capital Institute of Pediatrics in Beijing between February 2009 and December 2009. The levels of serum anti-CCP antibodies in 72 patients with JIA (33 boys, 39 girls; mean age 7.6±3.9 years; range 2 to 15.9 years), 65 patients with RA (14 boys, 51 girls; mean age 47±14.3 years; range 17 to 75 years), and 22 healthy children (10 boys, 12 girls; mean age 14.1±0.4 years; range 6.1 to 15.7 years) were measured using an enzyme-linked immunosorbent assay (ELISA). The obtained data along with the clinical data were analyzed. Results: The anti-CCP antibody positive rates for the JIA and RA groups were 12.5% and 73.85%, respectively, whereas the rate for the control group was 0% (p<0.001). The anti- CCP antibody positive rates of the polyarticular, oligoarticular, and systemic JIA groups were 31.25%, 14.8% and 0%, respectively (p<0.001). The rheumatoid factor (RF) positive rates, joint destruction rates, and mean disease courses of the positive and negative anti-CCP antibody groups were 66.7% versus 7.9% (chi-square=118.778, p<0.001), 33.3% versus 6.3% (chi-square=124.778, p<0.001), and 18.1 months versus 13.7 months (t=0.606, p=0.546), respectively. Conclusion: The anti-CCP antibody positive rate in patients with JIA is lower than for patients with RA. However this rate varies significantly according to the subtypes of JIA. Positive anti-CCP antibodies often indicate severe joint destruction

Özet

Amaç: Bu çalışmada jüvenil idiyopatik artrit (JIA) ve erişkin romatoid artrit (RA) hastalarında serum antisiklik sitrüline peptid (anti-CCP) antikor düzeyleri karşılaştırıldı ve bu antikorların JIA tanısındaki klinik değeri tartışıldı.Hastalar ve yöntemler: Çalışma Beijing Pediatri Capital Enstitüsü'nde Şubat 2009 - Aralık 2009 tarihleri arasında yapıldı. Yetmiş iki JIA hastasında (33 erkek, 39 kız; ort. yaş 7.6±3.9 yıl; dağılım 2-15.9 yıl), 65 RA hastasında (14 erkek, 51 kız; ort. yaş 47±14.3 yıl; dağılım 17-75 yıl) ve 22 sağlıklı çocuk hastada (10 erkek, 12 kız; ort. yaş 14.1±0.4 yıl; dağılım 6.1 to 15.7 yıl) serum anti-CCP antikor düzeyleri, enzim bağlı immünosorbent testi (ELISA) ile ölçüldü. Elde edilen veriler, klinik veriler ile birlikte analiz edildi.Bulgular: Jüvenil idiyopatik artrit ve RA gruplarının antiCCP antikor pozitif oranları, sırasıyla %12.5 ve %73.85 iken, bu oran kontrol grubunda %0 idi (p<0.001). Poliartiküler, oligoartiküler ve sistemik JIA gruplarının anti-CCP antikor pozitif oranı, sırasıyla %31.25, %14.8 ve %0 idi (p<0.001). Romatoid faktör (RF) pozitif oranları, eklem tahribatı oranları ve pozitif ve negatif anti-CCP antikor gruplarının ortalama hastalık süresi, sırasıyla %7.9'a kıyasla %66.7 (ki-kare=118.778, p<0.001), %6.3'e kıyasla %33.3 (ki-kare=124.778, p<0.001) ve 13.7 aya kıyasla 18.1 ay idi (t=0.606, p=0.546).Sonuç: Anti-CCP antikor pozitif oranı, JIA hastalarında, RA hastalarına kıyasla daha düşük olmakla birlikte, JIA'nın alt tiplerine göre büyük ölçüde değişiklik gösterir. Pozitif antiCCP antikorları, genellikle şiddetli eklem tahribatını gösterir

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Cite This Article

HUANG, X., XU, Z., WU, F., CUI, X., LI, X., CONG, X., ZHANG, J. (2012). Serum Antisiklik Sitrüline Peptid Antikorlarının Jüvenil İdiyopatik Artrit Açısından Klinik Değeri. Turkish Journal of Rheumatology(.)Archives of Rheumatology, Cilt: 27 - Sayı: 4, 221–226. https://ajindex.com/articles/375967

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