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Journals / Turkish Journal of Hematology / 2009 / Cilt: 26 - Sayı: 3

Bifenotipik lösemili bir çocukta kök hücre nakli sonrası granülositik sarkom

Granulocytic sarcoma after stem cell transplantation in a child with biphenotypic leukemia

ZÜHRE KAYA
Ülker KOÇAK
MERYEM ALBAYRAK
Türkiz GÜRSEL
Nalan AKYÜREK
Suna Özhan OKTAR
Pages
151–153
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Granulocytic sarcoma is an extramedullary tumor composed of leukemic blasts.
📊
Key Findings & Data:We report a case of isolated granulocytic sarcoma arising from the pleura in an 11-year-old girl who was previously treated for biphenotypic leukemia with allogeneic stem cell transplantation.
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Conclusion & Impact:The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · Kadın · Tekrarlama

Abstract

Granulocytic sarcoma is an extramedullary tumor composed of leukemic blasts. Isolated granulocytic sarcoma has rarely been reported in children with leukemia undergoing allogeneic stem cell transplantation. We report a case of isolated granulocytic sarcoma arising from the pleura in an 11-year-old girl who was previously treated for biphenotypic leukemia with allogeneic stem cell transplantation. Complete resolution of the tumor was achieved after two inductions with MRC 12 protocol; however, she died of sepsis during the neutropenic period. The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.

Özet

Granulositik sarkom, lösemik blastların oluşturduğu ekstrameduller bir tümördür. İzole granulositik sarkom, allogeneik kök hücre nakli yapılan lösemili çocuklarda nadiren bildirilmiştir. Bifenotipik lösemi relapsı nedeni ile allogeneik kök hücre nakli ile tedavi edilen ve izleminde plevra kaynaklı izole granulositik sarkom gelişen 11 yaşındaki kız olgu sunulmuştur. MRC 12 protokolüne göre iki indüksiyon tedavisi sonrası granulositik sarkomu tamamen kaybolan olgu, nötropenik dönemde gelişen sepsis nedeni ile kaybedilmiştir. Granulositik sarkomlu bu olguda olağandışı yerleşim, tanı ve relapsta immunfenotipik farklılık ve tedavi yaklaşımları tartışılmıştır.

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Cite This Article

KAYA, Z., KOÇAK, Ü., ALBAYRAK, M., GÜRSEL, T., AKYÜREK, N., OKTAR, S. Ö. (2009). Bifenotipik lösemili bir çocukta kök hücre nakli sonrası granülositik sarkom. Turkish Journal of Hematology, Cilt: 26 - Sayı: 3, 151–153. https://ajindex.com/articles/413369

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