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Journals / Turkish Journal of Pharmaceutical Sciences / 2010 / Cilt: 7 - Sayı: 1

Sophora jaubertii’ nin farklı ekstrelerinin alkaloit profilleri ve biyolojik aktiviteleri

Alkaloid profiles and biological activities of different sophora jaubertii extracts

Nurgün KÜÇÜKBOYACI
Nezaket ADIGÜZEL
Semiha ÖZKAN
FATMA TOSUN
Pages
1–8
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The remaining MIC values were found in the range of 62.5-500 μg/ml.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, the aerial parts and seeds of Sophora jaubertii Spach (leguminosae) growing in Turkey were investigated for their alkaloid compositions and antimicrobial activities.
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Key Findings & Data:The main components were identified as matrine (34.64 %), sophocarpine (15.32 %), cytisine (10.32 %), anagyrine (9.10 %), and sophoridine (6.35 %) in the aerial parts, while matrine (32.34 %), sophocarpine (14.67 %), cytisine (13.30 %), sophoranol (10.98 %), and sophoridine (8.57 %) in the seeds of the plant.
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Conclusion & Impact:The remaining MIC values were found in the range of 62.5-500 μg/ml.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, the aerial parts and seeds of Sophora jaubertii Spach (leguminosae) growing in Turkey were investigated for their alkaloid compositions and antimicrobial activities. The alkaloid extracts were analyzed by capillary gas chromatography-mass spectrometry (GC-MS). The main components were identified as matrine (34.64 %), sophocarpine (15.32 %), cytisine (10.32 %), anagyrine (9.10 %), and sophoridine (6.35 %) in the aerial parts, while matrine (32.34 %), sophocarpine (14.67 %), cytisine (13.30 %), sophoranol (10.98 %), and sophoridine (8.57 %) in the seeds of the plant. The alkaloid extracts were also evaluated for their antibacterial and antifungal activities. The alkaloid extract of the aerial parts of S. jaubertii presented significant activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) of 31.25 μg/ml. The remaining MIC values were found in the range of 62.5-500 μg/ml.

Özet

Bu çalışmada, Türkiye'de yetişen Sophora jaubertii Spach (Leguminosae) bitkisinin topraküstü kısımları ile tohumlarının alkaloit bileşimleri ve antimikrobiyal aktiviteleri incelenmiştir. Alkaloit ekstreleri kapiller gaz kromatografisi-kütle spektrometresi (GC-MS) ile analiz edilmiştir. Bitkinin toprak üstü kısmında matrin (% 34.64), sofokarpin (% 15.32), sitizin (% 10.32), anagirin (% 9.10) ve soforidin (% 6.35), tohumlarında ise matrin (% 32.34), sofokarpin (% 14.67), sitizin (% 13.30), soforanol (% 10.98) ve soforidin (% 8.57) başlıca bileşikler olarak tayin edilmiştir. Alkaloit ekstrelerinin ayrıca antibakteriyel ve antifungal aktiviteleri incelenmiştir. S. jaubertii'nin toprak üstü kısımlarının alkaloit ekstresi Bacillus subtilis'e karşı 31.25 μg/mL minimum inhibitor konsantrasyon (MİK) ile önemli bir aktivite göstermiştir. Diğer MIK değerleri 62.5-500 μg/mL arasında bulunmuştur.

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Cite This Article

KÜÇÜKBOYACI, N., ADIGÜZEL, N., ÖZKAN, S., TOSUN, F. (2010). Sophora jaubertii’ nin farklı ekstrelerinin alkaloit profilleri ve biyolojik aktiviteleri. Turkish Journal of Pharmaceutical Sciences, Cilt: 7 - Sayı: 1, 1–8. https://ajindex.com/articles/404095

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