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Journals / Turkish Journal of Pharmaceutical Sciences / 2006 / Cilt: 3 - Sayı: 2

Analjezik ve antienflamatuvar ajan olarak 2(3H)-benzotiyazolinon türevlerinin sentezi

Synthesis of 2(3H)-benzothiazolinone derivatives as analgesic and anti-inflammatory agents

YASEMİN DÜNDAR
Bilge ÇAKIR
Esra KÜPELİ
M. Fethi ŞAHİN
Pages
51–60
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compound 6c was found to have the highest analgesic and anti-inflammatory activity among the synthesized compounds.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, we have synthesized new 1-(4-(2-oxobenzothiazolin-3-yl)butyl-4-substituted piperazine, 1-(4-(2-oxobenzothiazolin-3-yl)butanoyl-4-substituted piperazine and 3-(4-(2-oxo-1,3-benzothiazol-2(3H)-yl)butyl)-1,3-benzothiazol-2(3H)-one derivatives and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in animals.
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Key Findings & Data:The chemical structures of these compounds were elucidated by their IR, 1H-NMR spectral data, and elementel analyses.
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Conclusion & Impact:Compound 6c was found to have the highest analgesic and anti-inflammatory activity among the synthesized compounds.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mide ülseri · Modeller · hayvan

Abstract

In this study, we have synthesized new 1-(4-(2-oxobenzothiazolin-3-yl)butyl-4-substituted piperazine, 1-(4-(2-oxobenzothiazolin-3-yl)butanoyl-4-substituted piperazine and 3-(4-(2-oxo-1,3-benzothiazol-2(3H)-yl)butyl)-1,3-benzothiazol-2(3H)-one derivatives and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in animals. The chemical structures of these compounds were elucidated by their IR, 1H-NMR spectral data, and elementel analyses. None of the compounds except compound 5b, 5c caused gastric lesions or bleeding in test animals. Compound 6c was found to have the highest analgesic and anti-inflammatory activity among the synthesized compounds.

Özet

Bu çalışmada, yeni 1-(4-(2-oksobenzotiyazolin-3-il) butil-4-sübstitüepiperazin, 1-(4-(2-oksobenzotiyazolin-3-il) butanoil-4-sübstitüepiperazin ve 3-(4-(2-okso-1,3-benzotiyazol-2(3H)-yl)butil)-1,3-benzotiyazol-2(3H)-on türevleri sentezlenmiş ve bunların analjezik ve antienflamatuvar aktiviteleri ile deney hayvanlarında gastrik ülser oluşturma potansiyelleri incelenmiştir. Bileşiklerin kimyasal yapıları IR, 1H-NMR ve elementel analiz verileri ile kanıtlanmıştır. Bileşik 5b, 5c dışında, hiçbir bileşik gastrik lezyon veya kanamaya neden olmamıştır. Bileşik 6c, sentezlenen bileşikler arasında en yüksek analjezik ve antienflamatuvar aktiviteye sahiptir

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Cite This Article

DÜNDAR, Y., ÇAKIR, B., KÜPELİ, E., ŞAHİN, M. F. (2006). Analjezik ve antienflamatuvar ajan olarak 2(3H)-benzotiyazolinon türevlerinin sentezi. Turkish Journal of Pharmaceutical Sciences, Cilt: 3 - Sayı: 2, 51–60. https://ajindex.com/articles/403857

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References (3)

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