AI Summary & Key Takeaways
AI InsightDuring the acute toxicity evaluation, neither death nor gastric bleeding was observed for any of the plant extracts
📌 3 Key Takeaways
Abstract
The aqueous extracts obtained from three Helichrysum species (Asteraceae) growing in Turkey, H. arenarium (L.) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss. and H. pilicatum DC. subsp. pilicatum, were evaluated for their in vivo anti-inflammatory activity using carrageenan-induced hind paw edema and antinociceptive activity using p-benzoquinone-induced abdominal constriction test. Aqueous extracts from H. arenarium and H. pilicatum subsp. pilicatum showed 37.0 %, 30.4 % inhibition at 100 mg/kg doses and 31.2%, 28.3% at 200 mg/kg doses in p-benzoquinone-induced abdominal constriction test, respectively, without inducing any gastric damage. The aqueous extracts of all the plants didn.t show any anti-inflammatory activity in carrageenan-induced hind paw edema model at 50, 100 and 200 mg/kg doses. During the acute toxicity evaluation, neither death nor gastric bleeding was observed for any of the plant extracts
Özet
Türkiye.de yetişen üç Helichrysum türünden (H. arenarium (L.) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss. and H. pilicatum DC. subsp. pilicatum) hazırlanan sulu ekstrelerin in vivo olarak anti-enflamatuar aktivitesi karragenin nedenli arka ayak ödemi testi ve antinosiseptif aktivitesi p-benzokinon nedenli kıvranma testi uygulanarak değerlendirilmiştir. H. arenarium ve H. pilicatum subsp. pilicatum sulu ekstreleri p-benzokinon nedenli kývranma testinde 100 mg/kg dozda sırasıyla % 37.0 ve % 30.4 oranında ve 200 mg/kg dozda % 31.2 ve % 28.3oranýnda herhangi bir gastric lezyon oluşturmaksızın inhibisyon göstermiştir. Karrageni- nedenli arka ayak ödemi testinde 50, 100 ve 200 mg/kg dozlarda ekstrelerin herhangi bir antienflamatuvar aktivitesi gözlenmemiştir. Akut toksisitelerine bakıldığında, ekstrelerin hiçbirisi herhangi bir gastric lezyon ya da ölüme sebep olmamıştır