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Journals / Turkish Journal of Pharmaceutical Sciences / 2008 / Cilt: 5 - Sayı: 1

1-Aril-3(benzimidazol-2-il)-pirazol-4-ketoksimlerin Pt(II) komplekslerinin sentezleri ve bu bileşiklerinin sitotoksik etkileri üzerine çalışmalar

Synthesis of platinum(II) complexes of 1-ARYL-3-(benzimidazole-2-YL)-pyrazole-4-ketoximes and studies on their cytotoxic effects

KADRİYE BENKLİ
İSMAİL KAYAĞİL
ZERRİN SELLER
GÜHERGÜL ULUÇAM
Şeref Demirayak
Pages
45–52
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this research, synthesis of some complexes in the presence of Pt(II) were studied.
📊
Key Findings & Data:The structure of the compounds were elucidated by IR, 'H-NMR, Mass and Elemental Analyses.
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Conclusion & Impact:The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this research, synthesis of some complexes in the presence of Pt(II) were studied. The structure of the compounds were elucidated by IR, 'H-NMR, Mass and Elemental Analyses. The cytotoxicity of Pt-complex was evaluated. The cellular responses through MTT method were measured in normal rat embryo fibroblast line F2408 and H-ras active-rat embryo fibroblast line 5RP7.

Özet

Bu çahsmada bazı l-Aril-3-(benzimidazol-2-il)-pirazol-4-ketoksim’lerin Pt(II) kompleksleri sentezlenmiştir. Bileşiklerin yapılan IR, 'H-NMR, Kittle ve elementel analiz He aydınlatılmistır. Pt(II) komplekslerinin sitotoksik etkileri araştmlmistır. Hücresel cevaplar, normal sican embriyo fibroblastı F2408 ve aktif sigan embriyo fibroblastında, MTT metodu kullamlarak ölqulmustür.

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Cite This Article

BENKLİ, K., KAYAĞİL, İ., SELLER, Z., ULUÇAM, G., Demirayak, Ş. (2008). 1-Aril-3(benzimidazol-2-il)-pirazol-4-ketoksimlerin Pt(II) komplekslerinin sentezleri ve bu bileşiklerinin sitotoksik etkileri üzerine çalışmalar. Turkish Journal of Pharmaceutical Sciences, Cilt: 5 - Sayı: 1, 45–52. https://ajindex.com/articles/403832

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