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Journals / Turkish Journal of Pharmaceutical Sciences / 2004 / Cilt: 1 - Sayı: 3

Bazı 6-kloro- ve 6,7-dikloro-2.3-disübstitüe-kinoksalin türevlerinin sentezi ve antitümör aktiviteleri

Synthesis and antitumor activity of some 6-chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline derivatives

Derya AKAR
Zerrin İNCESU
NALAN GÜNDOĞDU KARABURUN
KADRİYE BENKLİ
İlhan Işıkdağ
Pages
193–202
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Antitumor activities and cytotoxicities of the compounds were examined.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, 6-chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline derivatives were synthesized and their cytotoxicity and antitumor activities were tested. 6-Chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline compounds were obtained by reacting 1,2-dicarbonyl compound and substituted o-phenylenediamine under reflux for 4-5 hours in glacial acetic acid.
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Key Findings & Data:The structure elucidation of the compounds was performed by IR, 1H-NMR and Mass spectroscopic data and elemental analysis results.
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Conclusion & Impact:Antitumor activities and cytotoxicities of the compounds were examined.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Manyetik rezonans görüntüleme · Kinoksalinler · Spektrum analizi

Abstract

In this study, 6-chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline derivatives were synthesized and their cytotoxicity and antitumor activities were tested. 6-Chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline compounds were obtained by reacting 1,2-dicarbonyl compound and substituted o-phenylenediamine under reflux for 4-5 hours in glacial acetic acid. The structure elucidation of the compounds was performed by IR, 1H-NMR and Mass spectroscopic data and elemental analysis results. Antitumor activities and cytotoxicities of the compounds were examined.

Özet

Bu çalışmada, 6-kloro- ve 6,7-dikloro-2,3-disübstitüe-kinoksalin türevleri sentezlenerek, sitotoksisiteleri ve antitümör etkileri araştırıldı. 6-Kloro- ve 6,7-dikloro-2,3-disübstitüe-kinoksalin bileşikleri, uygun 1,2-dikarbonil bileşiği ve sübstitüe o-fenilendiamin ile, derişik asetik asit içerisinde, 4-5 saat geri çeviren soğutucu altında kaynatılarak elde edildi. Sentezlenen bileşiklerin yapıları IR, 1H-NMR ve Mass spektroskopik verileri ve elementel analiz sonuçları ile aydınlatıldı. Bileşiklerin antitümör aktiviteleri ve sitotoksisiteleri araştırıldı.

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Cite This Article

AKAR, D., İNCESU, Z., KARABURUN, N. G., BENKLİ, K., Işıkdağ, İ. (2004). Bazı 6-kloro- ve 6,7-dikloro-2.3-disübstitüe-kinoksalin türevlerinin sentezi ve antitümör aktiviteleri. Turkish Journal of Pharmaceutical Sciences, Cilt: 1 - Sayı: 3, 193–202. https://ajindex.com/articles/403898

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