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Journals / Turkish Journal of Pharmaceutical Sciences / 2014 / Cilt: 11 - Sayı: 1

Synthesis of Some Hydrazone Derivatives Bearing Purine Moiety as Anticancer Agents

Gülhan Turan ZITOUNI1, Mehlika Dilek ALTINTOP, Ahmet ÖZDEMİR1, , Zafer

Asım KAPLANCIKLI
MİRİŞ DİKMEN
Pages
55–66
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer cell lines

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(β- D-ribofuranosyl)-9H-purine with various benzaldehydes.
📊
Key Findings & Data:The structures of the compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR and ES-MS and elemental analyses.
💡
Conclusion & Impact:They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer cell lines
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(β- D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic techniques such as 1H-NMR, 13C-NMR and ES-MS and elemental analyses. Anti-prolif- erative activity tests were performed on human lung (A549) and breast (MCF-7) cancer cell lines using MTT assay. Some derivatives were found to be effective against A549 and MCF-7 cell lines among these compounds. They exhibited time and dose dependent anti-proliferative activity against A549 and MCF-7 cancer cell lines

Özet

Bu çalışmada, 6-hidrazino-9-(?-D-ribofuranosil)-9H-pürinin farklı benzaldehitler ile reaksiyonu sonucu bazı hidrazon türevleri sentezlenmiştir. Bileşiklerin yapıları 1H-NMR, 13C-NMR ve ES-MS gibi spektroskopik teknikler ve elemental analiz ile aydınlatılmıştır. MTT deneyi kullanılarak insan akciğer (A549) ve meme (MCF-7) kanser hücreleri üzerinde anti-proliferatif etki testleri gerçekleştirilmiştir. Bu bileşikler arasında, bazı türevlerin A549 ve MCF-7 hücrelerine karşı etkili olduğu bulunmuştur. Bu bileşikler A549 ve MCF-7 kanser hücrelerine karşı zamana ve doza bağımlı anti-proliferatif etki göstermişlerdir

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Cite This Article

KAPLANCIKLI, A., DİKMEN, M. (2014). Synthesis of Some Hydrazone Derivatives Bearing Purine Moiety as Anticancer Agents. Turkish Journal of Pharmaceutical Sciences, Cilt: 11 - Sayı: 1, 55–66. https://ajindex.com/articles/403750

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