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Journals / European Journal of Life Sciences / 2023 / Cilt: 2 Sayı: 1

Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives

Derya OSMANİYE
Uğur KAYİŞ
Ülküye Dudu GÜL
Yusuf ÖZKAY
Zafer Asım KAPLANCIKLI
Pages
1–24
Publication Date
2023-04-24
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The potential effectiveness of the compound 3e on the 14alpha-demethylase enzyme (PDB ID:3LD6) was tested by in silico studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs.
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Key Findings & Data:For this purpose, within the scope of this study, 7 new thiazole compounds were synthesized, and their structure determinations were carried out using HRMS, 1H-NMR, 13C-NMR spectroscopic methods.
💡
Conclusion & Impact:The potential effectiveness of the compound 3e on the 14alpha-demethylase enzyme (PDB ID:3LD6) was tested by in silico studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Thiazole · Antibacterial Activity · Antifungal Activity

Abstract

Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs. Therefore, there is a need for the development of new drug candidate compounds. The thiazole ring has many biological activities. It is possible to include antibacterial and antifungal activities among these activities. In addition to these, the thiazole ring has been preferred because it is the bioisostere of the imidazole ring in the structure of many antifungal drugs. For this purpose, within the scope of this study, 7 new thiazole compounds were synthesized, and their structure determinations were carried out using HRMS, 1H-NMR, 13C-NMR spectroscopic methods. Their antibacterial and antifungal activities were investigated by in vitro methods. As a result of activity tests, compound 3e showed activity against C.krusei strain with MIC50=31.25 ug/mL. The potential effectiveness of the compound 3e on the 14alpha-demethylase enzyme (PDB ID:3LD6) was tested by in silico studies.

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Cite This Article

OSMANİYE, D., KAYİŞ, U., GÜL, Ü. D., ÖZKAY, Y., KAPLANCIKLI, Z. A. (2023). Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives. European Journal of Life Sciences, Cilt: 2 Sayı: 1, 1–24. https://ajindex.com/articles/919613

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