IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON LİVER AND LUNG CANCER CELL LINES

Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans.

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Key Findings & Data:Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity.

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Conclusion & Impact:Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:A549 · apoptoz · HEP3B

Abstract

Objective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some reports indicate that it induces cellular apoptosis and toxicity. Our aim in this study is to determine the antiproliferative and antimigration effects of patulin on human liver and lung cancer cells and its effect on gene expressions in apoptotic pathways.

Özet

Amaç: Patulin, başta Aspergillus ve Penicilium olmak üzere bazı küf mantarları tarafından üretilen bir mikotoksin olup, hayvanlarda ve insanlarda mikotoksikozdan sorumludur. Patulinin antitümör aktivitesi hakkında hala çok ayrıntılı veriler bulunmamakla birlikte bazı raporlar hücresel apoptozu ve toksisiteyi indüklediğini göstermektedir. Bizim bu çalışmadaki amacımız patulinin insan karaciğer ve akciğer kanseri hücreleri üzerindeki antiproliferatif, antimigrasyon etkilerini ve apoptotik yolaklardaki gen ifadeleri üzerine etkisini belirlemektir.

Keywords

A549 apoptoz HEP3B kanser mikotoksin patulin apoptosis cancer mycotoxin

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Cite This Article

YÜCE, H., TÜRKMEN, N. B., ŞENKAL, S., ÖZEK, D. A., BULUT, E., DOĞAN, A., ÜNÜVAR, S. (2022). IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON LİVER AND LUNG CANCER CELL LINES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 46 - Sayı: 2, 393–404. https://ajindex.com/articles/401143

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References (3)

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