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Journals / Türk Uyku Tıbbı Dergisi / 2021 / Cilt: 8 - Sayı: 2

Evaluation of Inflammation in Restless Legs Syndrome

Huzursuz Bacaklar Sendromunda Enflamasyonun Değerlendirilmesi

Aylin REYHANİ
Vasfiye KABELOĞLU
Pages
136–141
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our study supports the role of inflammation in the pathogenesis of RLS.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Restless Legs syndrome (RLS) is a sleep disorder characterised by an irresistible urge to move the legs.
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Key Findings & Data:Materials and Methods: A total of 102 RLS patients and 51 healthy volunteers were included in the study.
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Conclusion & Impact:Our study supports the role of inflammation in the pathogenesis of RLS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Restless Legs syndrome (RLS) is a sleep disorder characterised by an irresistible urge to move the legs. The pathogenesis of RLS has not been clearly identified besides some new studies supporting the role of inflammation. The neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR) and monocyte-to-high-density lipoprotein cholesterol (HDL) ratio (MHR) have been used as markers of systemic inflammation recently. In this study, we aimed to investigate the role of inflammation in the pathogenesis of RLS by determining the levels of serum inflammatory biomarkers among RLS patients. Materials and Methods: A total of 102 RLS patients and 51 healthy volunteers were included in the study. Complete blood count, C-reactive protein, erythrocyte sedimentation rate, HDL, bilirubin and uric acid measurements, and NLR, PLR and MHR values were assessed and compared between the two groups. Results: RLS patients had higher values of neutrophil counts and lower values of lymphocyte counts compared to the control group (p=0.01 and p=0.02, respectively). The other parameters measured were similar for the two groups (all comparisons p>0.05). The NLR was statistically higher in RLS patients compared to the healthy volunteers, while both groups did not differ for the PLR and the MHR (p=0.01, p=0.47 and p=0.97, respectively). Conclusion: In this study, we demonstrated that RLS patients had high values of neutrophil counts, low values of lymphocyte counts and high NLR, which are consistent with the response to systemic inflammation. Our study supports the role of inflammation in the pathogenesis of RLS.

Özet

Amaç: Huzursuz Bacaklar sendromu (HBS) bacakları karşı konulamaz hareket ettirme ihtiyacı ile karakterize uyku bozukluğudur. HBS patogenezi tam olarak aydınlatılamamış olmakla beraber yapılan bazı yeni çalışmalar enflamasyonun da rol oynadığını desteklemektedir. Nötrofil-lenfosit oranı (NLO), platelet-lenfosit oranı (PLO) ve monosityüksek dansiteli lipoprotein kolesterol (HDL) oranı (MHO) son zamanlarda sistemik enflamasyonun göstergesi olarak kullanılmaya başlanılmıştır. Biz bu çalışmada HBS tanılı hastaların serumlarında enflamatuvar göstergeler olarak kabul edilen parametreleri ölçerek enflamasyonun HBS patogenezinde rolünü belirlemeyi amaçladık. Gereç ve Yöntem: HBS tanılı 102 olgu ve 51 sağlıklı gönüllü çalışmaya dahil edildi. Tam kan sayımı, C-reaktif protein, eritrosit sedimantasyon hızı, HDL, bilirubin, ürik asit ölçümleri ve NLO, PLO, MHO düzeyleri değerlendirildi ve iki grup arasında karşılaştırıldı. Bulgular: HBS tanılı hastalarda kontrol grubuna göre nötrofil değerleri daha yüksek ve lenfosit değerleri daha düşük bulundu (sırasıyla; p=0,01 ve p=0,02). Diğer ölçülen parametreler iki grup arasında benzerdi (p>0,05). NLO hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede yüksek bulunurken PLO ve MHO oranı ölçümlerinde iki grup arasında fark yoktu (sırasıyla p=0,01, p=0,47 ve p=0,97). Sonuç: Biz bu çalışmada HBS tanılı hastalarda, sistemik enflamasyona verilen cevap ile benzer şekilde, nötrofil sayısında artma, lenfosit sayısında azalma ve NLO artma olduğunu gösterdik. Bizim çalışmamız HBS patofizyolojisinde enflamasyonun rolü olduğunu desteklemektedir.

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Cite This Article

REYHANİ, A., KABELOĞLU, V. (2021). Evaluation of Inflammation in Restless Legs Syndrome. Türk Uyku Tıbbı Dergisi, Cilt: 8 - Sayı: 2, 136–141. https://ajindex.com/articles/394240

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References (14)

  1. Sonkaya AR, Ceylan M. Investigation of inflammation with neutrophil/lymphocyte ratio in restless legs syndrome. J Surg Med 2019;3:288-91
  2. Filiz MB, Çakır T. Restless legs syndrome with current diagnostic criteria. Turk J Osteoporos 2015;21:87-95
  3. American Academy of Sleep Medicine. International classification of sleep disorders, 3rd ed. Darien, IL: American Academy of Sleep Medicine, 2014
  4. Bayram SN, Egemen A. Restless legs syndrome. Türkiye Klinikleri J Pediatr 2007;16:245-54
  5. Higuchi T, Abe M, Mizuno M, Yamazaki T, Suzuki H, Moriuchi M, Oikawa O, Okawa E, Ando H, Okada K. Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis. Sleep Med 2015;16:941-8
  6. Ekbom KA. Restless legs: a clinical study. Acta Med Scand 1945;158:1-123
  7. Weinstock LB, Walters AS, Paueksakon P. Restless legs syndrome - theoretical roles of inflammatory and immune mechanisms. Sleep Med Rev 2012;16:341-54
  8. Varım C, Acar BA, Uyanık MS, Acar T, Alagoz N, Nalbant A, Kaya T, Ergenc H. Association between the neutrophil-to-lymphocyte ratio, a new marker of systemic inflammation, and restless legs syndrome. Singapore Med J 2016;57:514-6
  9. Tak AZA, Şengül Y. Evaluation of inflammation with neutrophil-tolymphocyte ratio and platelet-to-lymphocyte ratio in restless legs syndrome. Turk J Neurol 2018;24:259-63. 10. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14:R192. doi: 10.1186/cc9309
  10. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5-14
  11. Danese E, Montagnana M, Lippi G. Platelets and migraine. Thromb Res 2014;134:17-22
  12. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-632
  13. Yılmaz M, Kayançiçek H. A new ınflammatory marker: elevated monocyte to hdl cholesterol ratio associated with smoking. J Clin Med 2018;7:76
  14. Zhai R, Sheu CC, Su L, Gong MN, Tejera P, Chen F, Wang Z, Convery MP, Thompson BT, Christiani DC. Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. Tho