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AI InsightThe frequency of metabolic syndrome increased in patients with a high body mass index aftertotal thyroidectomy.
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Objectives: The literature about the frequency of metabolic syndrome in patients with multinodular goitre and anew onset of metabolic syndrome after total thyroidectomy is limited. The aim of this study was to investigate theeffects of total thyroidectomy and thyroid hormones on a new onset of metabolic syndrome in patients who underwent total thyroidectomy and have received thyroid hormone replacement.Material and Methods: Fifty-nine patients who underwent total thyroidectomy for multinodular goitre were included in this prospective study. Patients’ height, weight, and waist circumference were measured, and the body massindex was calculated. Peripheral blood samples were obtained preoperatively and at the 12th and 24th month aftertotal thyroidectomy to examine the lipid profile, glucose homeostasis, and thyroid function tests.Results: The lipid profile and blood pressure parameters deteriorated, and the mean body mass index and waistcircumference with the metabolic syndrome rates significantly increased at the 12th and 24th months follow-up.Preoperative body mass index (Exp[B] 1.60; p=0.003) was independently associated with metabolic syndrome at the2nd year after total thyroidectomyin a multivariate regression analysis.Conclusion: The frequency and severity of MetS is high in adult patients with non-toxic multinodular goitre aftertotal thyroidectomy. The frequency of metabolic syndrome increased in patients with a high body mass index aftertotal thyroidectomy.